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Study Title and Description

Altered processing of sweet taste in the brain of diet soda drinkers.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Altered processing of sweet taste in the brain of diet soda drinkers.
Author Green E, Murphy C.
Country San Diego State University/University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Year 2012
Numbers Pubmed ID: 22583859

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Saccharin
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Comparator Sucrose
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LCS vs sugar/ or others 1
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Outcomes differences in intensity and pleasantness ratings of the stimuli; areas of brain activation (fMRI and functional data were analyzed); (1) main effects of diet soda drinking; (2) main effect of caloric value on processing sweet taste in the brain; and (3) interactions between diet soda drinking and cortical activation to nutritive or nonnutritive sweet taste; examined through simple effects.; Correlations between activation to sucrose and saccharin in the amygdala; nucleus accumbens; and caudate head; body and tail and number of diet sodas per week in diet soda drinkers; comparison of brain reward regions
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Study Design nRCT-c
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Country/Region US
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Age (mean or range) 24
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Age 24
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% Male 0.42
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BMI 26
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Intervention Form Beverage
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Sample size 12
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Number analyzed (intervention) 7
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Number analyzed (control) 5
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Baseline health healthy
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Baseline health (coded) Healthy
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Duration <1d
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Duration (coded) <1 day
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brain 1
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glycaemia 0
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appetite 0
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dietary 0
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bodyweight 0
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Primary (Most important outcome) appetite
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Hypotheses/Aim(s) of Study Hypothesized both diet soda drinkers and non-drinkers would have widespead activation to sucrose in regions involved in taste(thalamus, anterior insula and reward(orbiofrontal cortex, caudate nucleus, amygdala) processing., and there would be less activation to saccharin in te higher-order limbic and reward regions for non-diet soda drinks, but smilar paterns for sucrose and saccharin in diet soda drinkers.
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Funding source NIH
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Funding(coded) Government
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Internal
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Results & Comparisons

No Results found.