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Study Title and Description

Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans.
Author Wu T, Zhao BR, Bound MJ, Checklin HL, Bellon M, Little TJ, Young RL, Jones KL, Horowitz M, Rayner CK.
Country Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, Australia.
Year 2011
Numbers Pubmed ID: 22158727

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Sucralose
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Comparator Glucose; 3OMG; TIM
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LCS vs sugar/ or others 1
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Outcomes blood glucose; insulin; GLP-1; GIP; gastric emptying; appetite sensation
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Study Design RCT-c
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Country/Region AU
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Age (mean or range) 28.8
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Age 28.8
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% Male 0.7
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BMI 25.5
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Intervention Form Beverage
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Sample size 10
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Number analyzed (intervention) 10
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Number analyzed (control) 10
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Baseline health healthy
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Baseline health (coded) Healthy
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Duration <1 day, 4 visits
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Duration (coded) <1 day
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brain 0
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glycaemia 1
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appetite 1
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dietary 0
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bodyweight 0
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study "The current study was designed to determine the comparative effects of preloads of glucose, 3OMG, a TIM, and sucralose on the release of GLP-1 and GIP, as well as gastric emptying of, and the glycemic response to, a subsequent meal in healthy humans."
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Funding source National Health and Medical Re- search Council (NHMRC) of Australia (grant no. 627139)
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Funding(coded) Government
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Internal
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