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Study Title and Description

Short-term consumption of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of hunger signaling and short-term glucose homeostasis in women.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Short-term consumption of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of hunger signaling and short-term glucose homeostasis in women.
Author Brown AW, Bohan Brown MM, Onken KL, Beitz DC.
Country Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA.
Year 2011
Numbers Pubmed ID: 22153513

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Sucralose
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Comparator Sucrose
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LCS vs sugar/ or others 1
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Outcomes glucose; insulin;glucagon; acylated ghrelin; well-being:hunger; tired
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Study Design RCT-c
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Country/Region US
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Age (mean or range) 21.75
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Age 21.75
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% Male 0
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BMI 22.16
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Intervention Form Beverage
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Sample size 8
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Number analyzed (intervention) 8
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Number analyzed (control) 8
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Baseline health healthy
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Baseline health (coded) Healthy
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Duration 180 min, 4 days
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Duration (coded) <1 day
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brain 0
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glycaemia 1
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appetite 1
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dietary 0
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bodyweight 0
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study In the present study, we hypothesized that the nonnutritive sweetener sucralose, a trichlorinated sucrose molecule, would elicit responses similar to water but different from sucrose and sucrose combined with sucralose on subjective and hormonal indications of hunger and short- term glucose homeostasis.
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Funding source Supported by grant USDA-CSREES number 2001- 38640-10270.
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Funding(coded) Government
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Internal
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Results & Comparisons

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