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Study Title and Description

Treatment of porto-systemic encephalopathy with lactitol verus lactulose: a randomized controlled study.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Treatment of porto-systemic encephalopathy with lactitol verus lactulose: a randomized controlled study.
Author Pai CH, Huang YS, Jeng WC, Chan CY, Lee SD.
Country Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Year 1995
Numbers Pubmed ID: 7712392

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Lactitol
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Comparator lactulose
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LCS vs sugar/ or others 2
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Outcomes palatability/pleasantness and preference; efficacy in inducing bowel mevement; and tolerability; changes in mental state; number connection test (NCT); asterixis; EEG and ammonia post-treatment; changes in portosystemic encephalopathy (PSE) index; days until gained consciousness post-treatment
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Study Design RCT-p
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Country/Region ASIA
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Age (mean or range) 66
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Age 66
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% Male nr
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BMI NR
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Intervention Form Sup or Oral
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Sample size 4
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Number analyzed (intervention) 21
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Number analyzed (control) 20
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Baseline health Portosystemic Encephalopathy patients
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Baseline health (coded) Other
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Duration <30d
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Duration (coded) 2 day - 1 month
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brain 1
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glycaemia 0
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appetite 0
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dietary 0
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bodyweight 0
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Primary (Most important outcome) taste
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Hypotheses/Aim(s) of Study Lactitol, a novel disaccharide analogue of lactulose, has been suggested as an alternative to lactulose in the treatment of portosystemic encephalopathy in Western country. In order to assess its therapeutic effect and adverse reaction in PSE in the Chinese, we conducted this study
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Funding source
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Funding(coded) NP
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Internal
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Results & Comparisons

No Results found.