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Study Title and Description

Comparing the effects of aspartame and sucrose on motivational ratings, taste preferences, and energy intakes in humans.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Comparing the effects of aspartame and sucrose on motivational ratings, taste preferences, and energy intakes in humans.
Author Drewnowski A, Massien C, Louis-Sylvestre J, Fricker J, Chapelot D, Apfelbaum M.
Country Program in Human Nutrition, University of Michigan School of Public Health, Ann Arbor 48109-2029.
Year 1994
Numbers Pubmed ID: 8310983

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Aspartame
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Comparator Sucrose
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LCS vs sugar/ or others 1
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Outcomes Ratings of: satiety; hunger; desire to eat; taste preferences; Energy intake per meal and per day; nutrient composition each day
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Study Design RCT-c
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Country/Region EU
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Age (mean or range) 25.4
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Age 25.4
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% Male 0.5
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BMI 21.8
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Intervention Form Food or Meal
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Sample size 24
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Number analyzed (intervention) 24
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Number analyzed (control) 24
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Baseline health Healthy nonsmokers and nondieters
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Baseline health (coded) Healthy
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Duration 4 days (1 day each week, always on the same day)
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Duration (coded) <1 day
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brain 1
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glycaemia 0
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appetite 1
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dietary 1
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bodyweight 0
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Primary (Most important outcome) appetite
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Hypotheses/Aim(s) of Study 1. Does the substitution of aspartame for sucrose in reduced energy foods lead to subsequent energy compensation or even energy rebound over a period of several hours as opposed to 60 mm? ,2. Does the addition of aspartame to plain foods lead to a stimulation of appetite and increased energy intake that extends beyond the first test meal? ,3. Does replacing sucrose with aspartame while keeping both energy and sweetness constant have an inhibitory effect on energy intake that may be due to the postingestive action of aspartame? ,4. What consistency, if any, is there between taste preference profiles, motivational ratings, and energy intakes, as measured in the same subjects over a period of several hours and under the same experimental conditions?
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Funding source NR
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Funding(coded) nr
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Internal
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