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Study Title and Description

Glycemic effect of a single high oral dose of the novel sweetener sucralose in patients with diabetes.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Glycemic effect of a single high oral dose of the novel sweetener sucralose in patients with diabetes.
Author Mezitis NH, Maggio CA, Koch P, Quddoos A, Allison DB, Pi-Sunyer FX.
Country Division of Endocrinology, Diabetes and Nutrition, St. Luke's-Roosevelt Hospital Center, New York, NY 10025, USA. nhm2@columbia.edu
Year 1996
Numbers Pubmed ID: 8875098

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Sucralose
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Comparator cellulose
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LCS vs sugar/ or others 2
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Outcomes glucose; serum C-peptide; episode of symptomatic hypoglycemia
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Study Design RCT-c
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Country/Region US
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Age (mean or range) 46.1
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Age 46.1
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% Male 0.6
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BMI 27.9
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Intervention Form Beverage
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Sample size 26
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Number analyzed (intervention) 26
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Number analyzed (control) 26
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Baseline health diabetes- type 1 (n=13) and type 2 (n=13)
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Baseline health (coded) Diabetic
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Duration 2 sessions (<1 day each), about 1 week apart
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Duration (coded) <1 day
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brain 0
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glycaemia 1
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appetite 0
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dietary 0
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bodyweight 0
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study Study Aim: examined the effect of a single high oral dose of sucralose on short-term glycemic control after a liquid break-fast in patients with IDDM or NIDDM.
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Funding source Grant from McNeil Specialty Prod-ucts Company
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Funding(coded) Industry
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Internal
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Results & Comparisons

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