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Study Title and Description

Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories.
Author Smeets PA, de Graaf C, Stafleu A, van Osch MJ, van der Grond J.
Country Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands. paul@isi.uu.nl
Year 2005
Numbers Pubmed ID: 16280432

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Aspartame
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Comparator Glucose, maltodextrin
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LCS vs sugar/ or others 1
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Outcomes signal changes in the upper anterior and posterior hypothalamus (UAH; UPH); plasma insulin; plasma glucose
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Study Design RCT-c
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Country/Region EU
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Age (mean or range) 20.4
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Age 20.4
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% Male 1
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BMI 21.7
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Intervention Form Beverage
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Sample size 5
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Number analyzed (intervention) 5
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Number analyzed (control) 5
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Baseline health healthy
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Baseline health (coded) Healthy
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Duration <1day
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Duration (coded) <1 day
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brain 1
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glycaemia 1
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appetite 0
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dietary 0
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bodyweight 0
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Primary (Most important outcome) taste
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Hypotheses/Aim(s) of Study
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Funding source Dutch Ministry of Education, Culture and Science, Dutch Ministry of Health, Welfare and Support
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Funding(coded) Government
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Internal
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Results & Comparisons

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