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Study Title and Description

Modified sham feeding of sweet solutions in women with anorexia nervosa.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Modified sham feeding of sweet solutions in women with anorexia nervosa.
Author Klein DA, Schebendach JE, Gershkovich M, Smith GP, Walsh BT.
Country Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. dk2127@columbia.edu
Year 2010
Numbers Pubmed ID: 20438741

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Aspartame
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Comparator none
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LCS vs sugar/ or others 2
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Outcomes effect on intake; self-reported (SR) liking; SR wanting; SR sweetness; hunger rating and desire to eat; binge and vomit (in anorexia vs normal patients)VAS
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Study Design RCT-c
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Country/Region US
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Age (mean or range) 25.6
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Age 25.6
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% Male 0
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BMI 16.1
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Intervention Form Sup or Oral
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Sample size 34
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Number analyzed (intervention) 24
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Number analyzed (control) 10
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Baseline health healthy (N=10), others (N=24)
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Baseline health (coded) Healthy
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Duration < 1 day
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Duration (coded) <1 day
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brain 0
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glycaemia 0
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appetite 1
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dietary 0
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bodyweight 0
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Primary (Most important outcome) appetite
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Hypotheses/Aim(s) of Study Hypothesis: at least a proportion of anorexia nervosa (AN) patients consume large quantities of non-caloric, arti´Čücially sweetened beverages (e.g., liters of "diet" beverages per day), and engage in chewing and spitting behavior ("naturalistic" forms of sham feeding); this sip-and-spit model of modified sham feeding providing sweet taste stimulation in the absence of calories would elicit larger intakes in patients with AN than controls.
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Funding source NIH
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Funding(coded) Government
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Internal
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Results & Comparisons

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