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Study Title and Description

Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects.
Author Ford HE, Peters V, Martin NM, Sleeth ML, Ghatei MA, Frost GS, Bloom SR.
Country Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Hammersmith Campus, Imperial College London, London, UK.
Year 2011
Numbers Pubmed ID: 21245879

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Sucralose
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Comparator maltodextrin
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LCS vs sugar/ or others 2
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Outcomes sweetness and palatability; appetite; food intake; plasma insulin; GLP-1; PYY; glucose
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Study Design RCT-c
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Country/Region EU
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Age (mean or range) 22-27
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Age .
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% Male 0.125
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BMI 18.8-23.9
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Intervention Form Beverage
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Sample size 8
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Number analyzed (intervention) 8
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Number analyzed (control) 8
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Baseline health healthy
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Baseline health (coded) Healthy
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Duration 4 sessions, < 1 day each (3 days minimum between sessions)
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Duration (coded) <1 day
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brain 1
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glycaemia 1
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appetite 1
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dietary 0
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bodyweight 0
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study Study aim: to investigate whether oral ingestion of sucralose, at a dose that would be consumed in a normal diet, increases circulating GLP-1 or PYY concentrations in man.
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Funding source - program grants from the MRC (G7811974), Wellcome Trust (072643/Z/03/Z) and by an EU FP6 Integrated Project Grant LSHM-CT-2003-50304,- NIHR Biomedical Research Centre funding scheme.
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Funding(coded) NP
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Internal
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Results & Comparisons

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