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Study Title and Description

Effects of diet soda on gut hormones in youths with diabetes.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Effects of diet soda on gut hormones in youths with diabetes.
Author Brown RJ, Walter M, Rother KI.
Country National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA. brownrebecca@mail.nih.gov
Year 2012
Numbers Pubmed ID: 22410815

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population mixed
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Intervention/Exposure Sucralose and acesulfame-K
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Comparator none (carbonated water)
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LCS vs sugar/ or others 2
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Outcomes glucose; C-peptide; GLP-1; GIP; PYY
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Study Design RCT-c
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Country/Region US
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Age (mean or range) 18.4
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Age 18.4
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% Male 0.368
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BMI 27
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Intervention Form Beverage
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Sample size 44
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Number analyzed (intervention) 44
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Number analyzed (control) 44
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Baseline health all overweight/obese;,diabetes (Type 1= 9, Type 2=10), healthy (control=25)
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Baseline health (coded) overweight
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Duration 2 sessions, <1 day each
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Duration (coded) <1 day
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brain 0
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glycaemia 1
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appetite 1
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dietary 0
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bodyweight 0
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study Study aim: 1) Whether subjects with diabetes (both type 1 and type2) would demonstrate increased GLP-1 secretion after ingestion of diet soda in addition to a glucose load, similar to the effect previously observed in healthysubjects. 2) Whether secretion of the gut hormones GIP and PYY are increased by ingestion of diet soda
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Funding source National Institute of Diabetes and Digestive and Kidney Diseases.
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Funding(coded) Government
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Internal
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Results & Comparisons

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