Advanced Search

Study Preview



Study Title and Description

Metabolic effects of replacing sucrose by isomaltulose in subjects with type 2 diabetes: a randomized double-blind trial.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Metabolic effects of replacing sucrose by isomaltulose in subjects with type 2 diabetes: a randomized double-blind trial.
Author Brunner S, Holub I, Theis S, Gostner A, Melcher R, Wolf P, Amann-Gassner U, Scheppach W, Hauner H.
Country Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Year 2012
Numbers Pubmed ID: 22492584

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
  • Comments Comments (
    0
    ) |
Intervention/Exposure Isomaltulose
  • Comments Comments (
    0
    ) |
Comparator Sucrose
  • Comments Comments (
    0
    ) |
LCS vs sugar/ or others 1
  • Comments Comments (
    0
    ) |
Outcomes HbA1c; fasting glucose; HOMA-IR (quantify insulin resistance); insulin; proinsulin; C-peptide; nonesterified fatty acids (NEFA); triglyceride
  • Comments Comments (
    0
    ) |
Study Design RCT-c
  • Comments Comments (
    0
    ) |
Country/Region EU
  • Comments Comments (
    0
    ) |
Age (mean or range) 60.6
  • Comments Comments (
    0
    ) |
Age 60.6
  • Comments Comments (
    0
    ) |
% Male 0.65
  • Comments Comments (
    0
    ) |
BMI 31.1
  • Comments Comments (
    0
    ) |
Intervention Form Food or Meal
  • Comments Comments (
    0
    ) |
Sample size 100
  • Comments Comments (
    0
    ) |
Number analyzed (intervention) 52
  • Comments Comments (
    0
    ) |
Number analyzed (control) 48
  • Comments Comments (
    0
    ) |
Baseline health diabetes, overweight/obese
  • Comments Comments (
    0
    ) |
Baseline health (coded) overweight
  • Comments Comments (
    0
    ) |
Duration 12 weeks
  • Comments Comments (
    0
    ) |
Duration (coded) 1 - 6 months
  • Comments Comments (
    0
    ) |
brain 0
  • Comments Comments (
    0
    ) |
glycaemia 1
  • Comments Comments (
    0
    ) |
appetite 0
  • Comments Comments (
    0
    ) |
dietary 0
  • Comments Comments (
    0
    ) |
bodyweight 0
  • Comments Comments (
    0
    ) |
Primary (Most important outcome) glycaemia
  • Comments Comments (
    0
    ) |
Hypotheses/Aim(s) of Study Study Aim: to examine whether replacing a daily intake of 50 g sucrose by isomaltulose in sweet foods and beverages over a period of 12 weeks would result in improved glycemic control in individuals with type 2 diabetes
  • Comments Comments (
    0
    ) |
Funding source Suedzucker AG, Mannheim/Ochsenfurt, Germany
  • Comments Comments (
    0
    ) |
Funding(coded) Industry
  • Comments Comments (
    0
    ) |
Internal
  • Comments Comments (
    0
    ) |




Results & Comparisons

No Results found.