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Study Title and Description

Aspartame and sucrose produce a similar increase in the plasma phenylalanine to large neutral amino acid ratio in healthy subjects.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Aspartame and sucrose produce a similar increase in the plasma phenylalanine to large neutral amino acid ratio in healthy subjects.
Author Burns TS, Stargel WW, Tschanz C, Kotsonis FN, Hurwitz A.
Country Preclinical and Clinical Research, NutraSweet Company, Deerfield, Ill.
Year 1991
Numbers Pubmed ID: 1771173

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Aspartame
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Comparator Sucrose
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LCS vs sugar/ or others 1
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Outcomes glucose; insulin; glucagon
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Study Design RCT-c
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Country/Region US
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Age (mean or range) 26.1
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Age 26.1
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% Male 0.5
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BMI .
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Intervention Form Beverage
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Sample size 8
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Number analyzed (intervention) 8
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Number analyzed (control) 8
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Baseline health healthy
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Baseline health (coded) Healthy
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Duration 1 week
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Duration (coded) 2 day - 1 month
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brain 0
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glycaemia 1
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appetite 0
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dietary 0
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bodyweight 0
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study To compare the magnitude of change in the plasma Phe/LNAA value following ingestion of asparatme-sweetened and sucrose-sweetened beverages of equivalent sweetness
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Funding source NutraSweet Company
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Funding(coded) Industry
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Internal
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