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Study Title and Description

The neuropsychiatric effects of aspartame in normal volunteers.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title The neuropsychiatric effects of aspartame in normal volunteers.
Author Lapierre KA, Greenblatt DJ, Goddard JE, Harmatz JS, Shader RI.
Country Department of Psychiatry, Tufts University School of Medicine, Boston, MA.
Year 1990
Numbers Pubmed ID: 2347957

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure Aspartame
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Comparator none
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LCS vs sugar/ or others 2
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Outcomes hunger; plasma glucose
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Study Design RCT-c
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Country/Region US
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Age (mean or range) 26.3
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Age 26.3
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% Male 0.6
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BMI NR
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Intervention Form Sup or Oral
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Sample size 10
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Number analyzed (intervention) 10
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Number analyzed (control) 10
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Baseline health healthy
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Baseline health (coded) Healthy
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Duration 2 sessions (<1 day each), at least 1 week apart
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Duration (coded) <1 day
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brain 0
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glycaemia 1
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appetite 1
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dietary 0
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bodyweight 0
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Primary (Most important outcome) appetite
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Hypotheses/Aim(s) of Study Study Aim: to determine whether normal volunteers, given a single dose of aspartame equivalent to approximately 2 L of aspartame-sweetened beverage under double-blind, placebo-controlled crossover conditions, would experience any of the effects which have been reported to the FDA.
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Funding source - Grants MH-34223 and AG-00106 from the US Public Health Service,- Grant-in-Aid from the NutraSweet Company
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Funding(coded) Government
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Internal
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