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Study Title and Description

Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized,placebo-controlled study.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized,placebo-controlled study.
Author Hsieh MH1, Chan P, Sue YM, Liu JC, Liang TH, Huang TY, Tomlinson B, Chow MS, Kao PF, Chen YJ.
Country Department of Medicine, Taipei Medical University--Wan Fang Hospital, Taipei City, Taiwan.
Year 2003
Numbers Pubmed ID: 14693305

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure stevioside
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Comparator placebo
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LCS vs sugar/ or others 2
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Outcomes blood pressure; serum (Cr; CPK; AST; ALT; sodium; potassium; chloride); glucose; total cholesterol; HDL; TG; BMI; left ventricular mass index; quality of life
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Study Design RCT-p
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Country/Region ASIA
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Age (mean or range) 20-75
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Age
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% Male 0.51
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BMI 23
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Intervention Form Sup or Oral
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Sample size 168
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Number analyzed (intervention) 82
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Number analyzed (control) 86
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Baseline health Hypertensive
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Baseline health (coded) Other
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Duration 2 years
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Duration (coded) >1 year
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brain 0
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glycaemia 1
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appetite 0
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dietary 0
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bodyweight 1
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study To investigate the long-term 2 year efficacy and tolerability of stevioside in patients with mild essential hypertension, and to determine the effects of stevioside on left ventricular mass index and quality of life
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Funding source University and Hospital
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Funding(coded) NP & Industry
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Internal
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Results & Comparisons

No Results found.