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Study Title and Description

Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjectsbut not in patients with type 2 diabetes.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjectsbut not in patients with type 2 diabetes.
Author Temizkan S1, Deyneli O1, Yasar M1, Arpa M2, Gunes M1, Yazici D1, Sirikci O2, Haklar G2, Imeryuz N3, Yavuz DG1.
Country Department of Endocrinology and Metabolic Diseases, Marmara University Faculty of Medicine, Istanbul, Turkey.
Year 2014
Numbers Pubmed ID: 25271009

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure aspartame and sucralose
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Comparator water
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LCS vs sugar/ or others 2
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Outcomes glucose; insulin; c-peptide; GLP-1. BMI; HbA1c
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Study Design RCT-c
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Country/Region EU
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Age (mean or range) 48
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Age 48
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% Male 0.5
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BMI
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Intervention Form Beverage
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Sample size 16
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Number analyzed (intervention) 16
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Number analyzed (control) 16
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Baseline health diabetes and healthy
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Baseline health (coded) mixed
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Duration 1 day
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Duration (coded) <1 day
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brain 0
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glycaemia 1
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appetite 0
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dietary 0
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bodyweight 1
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study To examine acute effect of artificial sweeteners on gut hormones insulin, c-peptide and glucose
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Funding source
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Funding(coded) NP
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Internal
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Results & Comparisons

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