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Study Title and Description

Aspartame ingestion with and without carbohydrate in phenylketonuric and normal subjects: effect on plasmaconcentrations of amino acids, glucose, and insulin.



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Aspartame ingestion with and without carbohydrate in phenylketonuric and normal subjects: effect on plasmaconcentrations of amino acids, glucose, and insulin.
Author Wolf-Novak LC1, Stegink LD, Brummel MC, Persoon TJ, Filer LJ Jr, Bell EF, Ziegler EE, Krause WL
Country Department of Pediatrics, University of Iowa College of Medicine, Iowa City.
Year 1990
Numbers Pubmed ID: 2182973

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure aspartame
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Comparator carbohydrate
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LCS vs sugar/ or others 2
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Outcomes plasma amino acid concentration; (PHD; LNAA); insulin; glucose; weight
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Study Design RCT-c
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Country/Region US
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Age (mean or range) 16-27
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Age
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% Male nr
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BMI nr
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Intervention Form Beverage
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Sample size 14
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Number analyzed (intervention) 7
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Number analyzed (control) 7
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Baseline health PKU and healthy
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Baseline health (coded) mixed
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Duration 8 weeks
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Duration (coded) 1 - 6 months
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brain 0
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glycaemia 1
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appetite 0
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dietary 0
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bodyweight 1
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Primary (Most important outcome) glycaemia
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Hypotheses/Aim(s) of Study Investigated effect of ingesting carbohydrate with unsweetened APM-sweetened beverage on plasma amino acid concentrations of normal and PKU patients
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Funding source grant from general clinical research center NIH
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Funding(coded) Government
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Internal
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Results & Comparisons

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