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Study Title and Description

Multiple receptor sites mediate sweetness: evidence from cross adaptation.2



Key Questions Addressed
1 What are the association between low-calorie sweeteners and health?
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Primary Publication Information
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TitleData
Title Multiple receptor sites mediate sweetness: evidence from cross adaptation.2
Author Schiffman SS, Cahn H, Lindley MG.2
Country
Year 1981
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: LCS-RCT
Design Details
Question... Follow Up Answer Follow-up Answer
Population Adults
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Intervention/Exposure - Acetosulfam- Aspartame- rebaudioside A- sodium Saccharin- Sorbitol- Xylitol- Neohesperidin dihydrochalcone
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Comparator - Ca cyclamate,- Fructose,- galactose,- Glucose,- maltose,- D-tryptophan,- xylose
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LCS vs sugar/ or others 1
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Outcomes differences in perceived sweetness after adaptation (cross adapted with one another); difference between means of perceived sweetness preand post-adaptation
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Study Design RCT-c
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Country/Region US
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Age (mean or range) 18-21
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Age .
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% Male 0.43
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BMI nr
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Intervention Form Beverage
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Sample size 151
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Number analyzed (intervention) nr
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Number analyzed (control) nr
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Baseline health healthy
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Baseline health (coded) Healthy
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Duration <1day
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Duration (coded) <1 day
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brain 1
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glycaemia 0
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appetite 0
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dietary 0
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bodyweight 0
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Primary (Most important outcome) taste
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Hypotheses/Aim(s) of Study The purpose of this study was to extend the method of cross adaptiation to a wider range of compound with varying structures to examine further wehter only one recetpor type mediates sweetness as suggested previously, or wether the sweet taste is similar to the bitter taste, which has been found to be mediated by multiple receptor types
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Funding source NIA
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Funding(coded) NP
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Results & Comparisons

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