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Study Title and Description

Cloned enzyme donor immunoassay tacrolimus assay compared with high-performance liquid chromatography-tandem mass spectrometry and microparticle enzyme immunoassay in liver and renal transplant recipients.



Key Questions Addressed
1 In adult renal transplants, how do liquid chromatographic and mass spectrometric analytical techniques compare with immunoassay analysis for therapeutic monitoring of full dosing regimens of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus? AND In adult renal transplants, how do liquid chromatographic and mass spectrometric analytical techniques compare with immunoassay analysis for therapeutic monitoring of lower CNI doses used in minimization, conversion, or withdrawal strategies?
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Primary Publication Information
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TitleData
Title Cloned enzyme donor immunoassay tacrolimus assay compared with high-performance liquid chromatography-tandem mass spectrometry and microparticle enzyme immunoassay in liver and renal transplant recipients.
Author Westley IS., Taylor PJ., Salm P., Morris RG.
Country Department of Cardiology and Clinical Pharmacology, The Queen Elizabeth Hospital, Woodville, South Australia.
Year 2007
Numbers Pubmed ID: 17898648

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Therapeutic Monitoring
Arms
Number Title Description Comments
1 HPLC-MS
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2 CEDIA and MEIA
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Design Details
Question... Follow Up Answer Follow-up Answer
STUDY DESIGN Retrospective comparison of analytical performance of tests
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Results & Comparisons

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