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Study Title and Description

Comparison of an ELISA and an LC/MS/MS method for measuring tacrolimus concentrations and making dosage decisions in transplant recipients.



Key Questions Addressed
1 In adult renal transplants, how do liquid chromatographic and mass spectrometric analytical techniques compare with immunoassay analysis for therapeutic monitoring of full dosing regimens of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus? AND In adult renal transplants, how do liquid chromatographic and mass spectrometric analytical techniques compare with immunoassay analysis for therapeutic monitoring of lower CNI doses used in minimization, conversion, or withdrawal strategies?
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Primary Publication Information
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TitleData
Title Comparison of an ELISA and an LC/MS/MS method for measuring tacrolimus concentrations and making dosage decisions in transplant recipients.
Author Staatz CE., Taylor PJ., Tett SE.
Country School of Phamacy, University of Queensland, Princess Alexandra Hospital, Queensland, Australia. c.staatz@pharmacy.uq.edu.au
Year 2002
Numbers Pubmed ID: 12352932

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Therapeutic Monitoring
Arms
Number Title Description Comments
1 LC-MS/MS
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2 ELISA
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Design Details
Question... Follow Up Answer Follow-up Answer
STUDY DESIGN Retrospective comparison of analytical performance
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Results & Comparisons

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