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Study Title and Description

High-performance liquid chromatography-tandem mass spectrometry as a reference for analysis of tacrolimus to assess two immunoassays in patients with liver and renal transplants.



Key Questions Addressed
1 In adult renal transplants, how do liquid chromatographic and mass spectrometric analytical techniques compare with immunoassay analysis for therapeutic monitoring of full dosing regimens of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus? AND In adult renal transplants, how do liquid chromatographic and mass spectrometric analytical techniques compare with immunoassay analysis for therapeutic monitoring of lower CNI doses used in minimization, conversion, or withdrawal strategies?
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Primary Publication Information
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TitleData
Title High-performance liquid chromatography-tandem mass spectrometry as a reference for analysis of tacrolimus to assess two immunoassays in patients with liver and renal transplants.
Author Salm P., Taylor PJ., Clark A., Balderson GA., Grygotis A., Norris RL., Lynch SV., Shaw LM., Pond SM.
Country Department of Clinical Pharmacology, The University of Queensland, Brisbane, Australia.
Year 1997
Numbers Pubmed ID: 9421113

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Therapeutic Monitoring
Arms
Number Title Description Comments
1 HPLC-MS
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2 ELISA and MEIA
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Design Details
Question... Follow Up Answer Follow-up Answer
STUDY DESIGN Prospective comparison of analytical performance
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Results & Comparisons

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