Advanced Search

Study Preview



Study Title and Description

A method of relating whole blood cyclosporin A results by HPLC to Abbott TDx monoclonal and polyclonal immunoassays.



Key Questions Addressed
1 In adult renal transplants, how do liquid chromatographic and mass spectrometric analytical techniques compare with immunoassay analysis for therapeutic monitoring of full dosing regimens of the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus? AND In adult renal transplants, how do liquid chromatographic and mass spectrometric analytical techniques compare with immunoassay analysis for therapeutic monitoring of lower CNI doses used in minimization, conversion, or withdrawal strategies?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title A method of relating whole blood cyclosporin A results by HPLC to Abbott TDx monoclonal and polyclonal immunoassays.
Author Roberts NB., Dutton J., Tewari A., Bone MJ., Sells RA., Ward RG., West CR.
Country Department of Clinical Chemistry, Royal Liverpool University Hospital, UK.
Year 1995
Numbers Pubmed ID: 7785951

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Therapeutic Monitoring
Arms
Number Title Description Comments
1 HPLC-MS
  • Comments Comments (
    0
    ) |
2 Abbott TDx mono- and poly-clonal immunoassay
  • Comments Comments (
    0
    ) |

Design Details
Question... Follow Up Answer Follow-up Answer
STUDY DESIGN Prospective comparison of analytical performance
  • Comments Comments (
    0
    ) |




Results & Comparisons


Results Data
Outcome: Analytic accuracy      Population: All Participants
Time Point Measure HPLC-MS Abbott TDx mono- and poly-clonal immunoassay


Enter a numeric value or title (required) years

N Analyzed
Counts
Outcome: Analytic bias      Population: All Participants
Time Point Measure HPLC-MS Abbott TDx mono- and poly-clonal immunoassay


Enter a numeric value or title (required) years

N Analyzed
Counts