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Study Title and Description

Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption



Key Questions Addressed
2 What are the relationships between fructose consumption and indices of liver health?
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5 Risk of Bias - Cross-Sectional Studies
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Primary Publication Information
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TitleData
Title Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption
Author Davis et al.
Country
Year 2010
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Fructose and NAFLD
Arms
Number Title Description Comments
1 Cross Sectional Design
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Cross-sectional
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Enrollment Years nd
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Trial or Cohort Name nd
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Funding Source -National Institute of Diabetes and Digestive and Kidney Diseases Mentored K01 Award -MGM Mirage Fund at the University of Southern California (Other organizations listed as "support" but financials not mentioned)
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Inclusion Criteria Pooled subjects from a variety of studies using essentially identical protocols and measures conducted by the USC Childhood Obesity Research Center over 6 years. Subjects were recruited from schools, community centers, health clinics, health fairs. -Hispanic Ancestry (All 4 grandparents, ages 8-18 years) -Complete genotype, visceral, subcutaneous and liver fat, and dietary intake data were available.
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Location -intake of medications known to affect body composition -present syndromes or diseases that affect body fat and/or composition -any other major illnesses -participation in structured exercise, nutrition, or weight loss program within the 6 months before recruitment
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Confounders Yes
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Energy intake
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Yes
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Sex, Age
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Yes
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BMI, visceral adipose tissue
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No
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No
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No
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No
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No
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No
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Added sugar intake was analyzed in %kcal/day, or g/d with energy as a covariate
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Counfounders Yes
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Baseline Characteristics
Question Cross Sectional Design Total Comments
AnswerFollow-up AnswerFollow-up
N Enrolled nd
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N Analyzed 153
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Mean (SD) Age, yrs CC (n=38) 13.3 ± 3.0 CG (n=70) 14.1 ± 2.9 GG (n=45) 14.0 ± 2.9
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Age range (IQR) 8-18 yrs
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Male % 25
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Anthropometry data BMI BMI CC (n=38) 30.7 ± 8.6 CG (n=70) 31.4 ± 7.5 GG (n=45) 32.5 ± 8.6
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Other BMI percentile CC (n=38) 91.7 CG (n=70) 94.7 GG (n=45) 95.7
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Alcohol Intake nd
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Co-morbidity (other diseases/conditions) None
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Other important baseline characteristics or baseline confounders Hepatic fat (%) CC (n=38) 4.5 ± 4.1 CG (n=70) 5.9 ±5.8 GG (n=45) 9.7 ±8.1 (p<0.001 compared with CC, CG)
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Background Diet -Added sugars defined as those with sugars/syrups added to foods during food preparation or processing
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Three 24 hour dietary recalls (n=30) 3 day diet records (n=123) (no differences in macronutrients or energy between methods) (all records administered or clarified by bilingual dietary technician)
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Nutrition Data System for Research
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Data were examined for plausibility of caloric intake (residuals of the linear regression). There were no nonpausible data.
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Total Energy (kcal) CC (n=38): 1801.2 ± 575.4 CG (n=70):1850.6 ± 544.8 GG (n=45): 1599.4 ± 463.9 Total sugar (g/d) CC (n=38): 112.0 CG (n=70): 104.3 GG (n=45): 96.1 Total sugar (%energy) CC (n=38): 24.7 CG (n=70): 22.7 GG (n=45): 23.7
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Race/Ethnicity Hispanic
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Results & Comparisons


Results Data
Outcome: Hepatic Fat Fraction, HFF (%)      Population: All Participants
Time Point Measure Cross Sectional Design


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Results
Comments

Adverse Events
Arm or Total Title Description Comments
Cross Sectional Design Not Reported
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Total

Extraction Form: Case Control & Cross Sectional Quality


Results & Comparisons


Results Data
Outcome: Hepatic Fat Fraction, HFF (%)      Population: All Participants
Time Point Measure Cross Sectional Design


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Results
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Quality Dimensions
Dimension Value Notes Comments
1) Is the case definition adequate? a
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2) Representativeness of the cases b
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3) Selection of controls n/a
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4) Definition of controls n/a
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5) Comparability of cases and controls on the basis of the design or analysis: age and sex n/a
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6) Comparability of cases and controls on the basis of the design or analysis: anthropometrics n/a
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7) Comparability of cases and controls on the basis of the design or analysis: nutrient and energy intake n/a
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8) Ascertainment of exposure b
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9) Same method of ascertainment for cases and controls n/a
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10) Description of a validated method to quantify the amount, per type, of nutrients of interest a
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11) Non-response rate c
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Quality Rating
Guideline Used Overall Rating
Medium