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Study Title and Description

Dietary and physical activity patterns in children with fatty liver



Key Questions Addressed
2 What are the relationships between fructose consumption and indices of liver health?
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5 Risk of Bias - Cross-Sectional Studies
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Primary Publication Information
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TitleData
Title Dietary and physical activity patterns in children with fatty liver
Author Mager et al.
Country
Year 2010
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Fructose and NAFLD
Arms
Number Title Description Comments
1 Cross Sectional 3 day food record of children with fatty liver
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Cross-sectional
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Enrollment Years April 2005-May 2006
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Trial or Cohort Name nd
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Funding Source Canadian Association of Gastroenterology/Nestle/CIHR Pediatric Nutrition Fellowship award and the Metabolism Research Program/Mead-Johnson Fund of the Hospital for Sick Children Research Institute
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Inclusion Criteria -5-19 years old -abnormal liver tests or abnormal hepatic sonography showing fatty liver (from Liver Clinic at The Hospital for Sick Children)
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Exclusion Criteria -presence of Wilson’s disease, cystic fibrosis, and various inherited metabolic disorders that could possibly be associated with fatty liver - treatment with medications known to cause hepatic steatosis, diabetes mellitus, splenomegaly, or ascites.
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Location Canada
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Confounders No
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NA
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Yes
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Age
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Yes
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BMI
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No
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NA
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No
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NA
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No
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NA
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No
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NA
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Yes
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Adiponectin, Tg
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Counfounders Yes
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Baseline Characteristics
Question Cross Sectional 3 day food record of children with fatty liver Total Comments
AnswerFollow-up AnswerFollow-up
N Enrolled 38
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N Analyzed 35
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Mean (SD) Age, yrs 14.1 (3.2)
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Age range (IQR) 5.5-19.9
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Male % 68%
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Anthropometry data BMI 30.2 ± 5.3
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BMI z score 1.99 ± 0.68
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Alcohol Intake nd
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Co-morbidity (other diseases/conditions) nd
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Other important baseline characteristics or baseline confounders nd
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Background Diet na
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Three-day food intake records (two weekdays one weekend day) with portion sizes and food type with brand names
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Micro- and-macronutrient content of the diet was determined by Diet Analysis Plus Software Version 4 1999. Sucrose, fructose, and selenium content of the diet were determined using the USDA database
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n/a (diet records)
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Energy (kcal/day) = 1174.9 ± 384.6 Sucrose (g) = 23.3 ± 17.3 Fructose (g) = 21.6 ± 13.0
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Race/Ethnicity 48% Caucasian 28% Hispanic 21% Asian 3% Other
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Results & Comparisons


Results Data
Outcome: All outcomes      Population: All Participants
Time Point Measure Cross Sectional 3 day food record of children with fatty liver


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Results
Comments
Outcome: AST      Population: All Participants
Time Point Measure Cross Sectional 3 day food record of children with fatty liver


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Results for ALL outcomes

Adverse Events
Arm or Total Title Description Comments
Cross Sectional 3 day food record of children with fatty liver Not Reported
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Total

Extraction Form: Case Control & Cross Sectional Quality


Results & Comparisons


Results Data
Outcome: All outcomes      Population: All Participants
Time Point Measure Cross Sectional 3 day food record of children with fatty liver


0 N/A

Results
Comments
Outcome: AST      Population: All Participants
Time Point Measure Cross Sectional 3 day food record of children with fatty liver


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Results for ALL outcomes


Quality Dimensions
Dimension Value Notes Comments
1) Is the case definition adequate? a ultrasound and blood test
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2) Representativeness of the cases b all NAFLD children
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3) Selection of controls n/a
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4) Definition of controls n/a
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5) Comparability of cases and controls on the basis of the design or analysis: age and sex n/a
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6) Comparability of cases and controls on the basis of the design or analysis: anthropometrics n/a
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7) Comparability of cases and controls on the basis of the design or analysis: nutrient and energy intake n/a
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8) Ascertainment of exposure n
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9) Same method of ascertainment for cases and controls n/a
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10) Description of a validated method to quantify the amount, per type, of nutrients of interest a
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11) Non-response rate c
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Quality Rating
Guideline Used Overall Rating
High