Advanced Search

Study Preview



Study Title and Description

Fructose consumption as a risk factor for non-alcoholic fatty liver disease.



Key Questions Addressed
1 What is the effect of fructose consumption on the risk of NAFLD? a) Is there a dose-response relationship between fructose intake and NAFLD? b) Does the relationship between fructose intake and NAFLD exhibit a threshold effect within or beyond the range of typical fructose intakes? c) What factors modify the effect of fructose consumption on NAFLD?
  • Comments Comments (
    0
    ) |
5 Risk of Bias - Cross-Sectional Studies
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Fructose consumption as a risk factor for non-alcoholic fatty liver disease.
Author Ouyang X., Cirillo P., Sautin Y., McCall S., Bruchette JL., Diehl AM., Johnson RJ., Abdelmalek MF.
Country Division of Nephrology, University of Florida, Gainesville, FL, USA.
Year 2008
Numbers Pubmed ID: 18395287
716 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Fructose and NAFLD
Arms
Number Title Description Comments
1 NAFLD
  • Comments Comments (
    0
    ) |
2 Controls convenience sampling (patients who underwent a liver biopsy for the evaluation of underlying liver disease and who were deemed to have no identifiable cause for chronic liver disease).
  • Comments Comments (
    0
    ) |

Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Case-control
  • Comments Comments (
    0
    ) |
Enrollment Years nd
  • Comments Comments (
    0
    ) |
Trial or Cohort Name nd
  • Comments Comments (
    0
    ) |
Funding Source NIH and Gatorade, (pg 998)
  • Comments Comments (
    0
    ) |
Inclusion Criteria Cases: biopsy proven NAFLD in Liver Clinics. The presence of NAFLD was established by a comprehensive medical history, the presence of abnormal liver aminotransferases, negative serologies for alternative forms of chronic liver disease (i.e. viral, autoimmune or metabolic liver disease), hyperechoic liver by ultrasound imaging, and histologic features Controls: convenience sampling (patients who underwent a liver biopsy for the evaluation of underlying liver disease and who were deemed to have no identifiable cause for chronic liver disease). Controls were matched by age (±5 years), gender and BMI (±3 points) to NAFLD cases.
  • Comments Comments (
    0
    ) |
Exclusion Criteria -Excessive alcohol intake (20g/wk) -Viral, autoimmune, or metabolic liver diseases -controls (for KHK) – fatty liver or specific histological features of NAFLD
  • Comments Comments (
    0
    ) |
Location US
  • Comments Comments (
    0
    ) |
Confounders Yes
  • Comments Comments (
    0
    ) |
Excessive Alcohol Intake
  • Comments Comments (
    0
    ) |
Yes
  • Comments Comments (
    0
    ) |
Age, sex
  • Comments Comments (
    0
    ) |
Yes
  • Comments Comments (
    0
    ) |
BMI
  • Comments Comments (
    0
    ) |
No
  • Comments Comments (
    0
    ) |
No
  • Comments Comments (
    0
    ) |
No
  • Comments Comments (
    0
    ) |
No
  • Comments Comments (
    0
    ) |
No
  • Comments Comments (
    0
    ) |
No further reporting and adjusting for any other potential confounders. Matched by age, sex and BMI
  • Comments Comments (
    0
    ) |
Yes
  • Comments Comments (
    0
    ) |
Counfounders Yes
  • Comments Comments (
    0
    ) |


Baseline Characteristics
Question NAFLD Controls Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up
N Enrolled 49 24 73
  • Comments Comments (
    0
    ) |
N Analyzed 49 24 73
  • Comments Comments (
    0
    ) |
Mean (SD) Age, yrs nd nd nd
  • Comments Comments (
    0
    ) |
Age range (IQR) nd nd nd
  • Comments Comments (
    0
    ) |
Male % nd nd nd
  • Comments Comments (
    0
    ) |
Anthropometry data No data entered.
Alcohol Intake <20g/wk
  • Comments Comments (
    0
    ) |
Co-morbidity (other diseases/conditions) nd nd nd
  • Comments Comments (
    0
    ) |
Other important baseline characteristics or baseline confounders nd nd nd
  • Comments Comments (
    0
    ) |
Background Diet Energy from fructose in fructose containing beverages
  • Comments Comments (
    0
    ) |
Dietary recall/histories of routine daily consumption fructose containing beverages over a 3 months period (performed within 1 month of the liver biopsy).
  • Comments Comments (
    0
    ) |
nd (Total energy consumption (kcal/day) from daily fructose intake was estimated based on reporting (frequency x amount) of kool-aid, fruit juices, and non-dietary soda per week)
  • Comments Comments (
    0
    ) |
no
  • Comments Comments (
    0
    ) |
Only reported energy from HFCS or sugar containing beverages (see results)
  • Comments Comments (
    0
    ) |
Race/Ethnicity nd nd nd
  • Comments Comments (
    0
    ) |



Results & Comparisons


Results Data
Adj. P-Value
Outcome: NAFLD      Population: All Participants Between-Arm Comparisons
Time Point Measure NAFLD Controls Comparison Measure ERROR vs. ERROR


1 months

N Analyzed 49 24 <0.05
Crude or Adjusted Analysis Adj Adj
Mean Fructose Level 356 170
Fructose level 95% Confidence Interval nd (a bar graph was reported but not sure what was the range) nd (a bar graph was reported but not sure what was the range)
Comments

Adverse Events
Arm or Total Title Description Comments
NAFLD Not Reported
  • Comments Comments (
    0
    ) |
Controls
Total

Extraction Form: Case Control & Cross Sectional Quality


Results & Comparisons


Results Data
Adj. P-Value
Outcome: NAFLD      Population: All Participants Between-Arm Comparisons
Time Point Measure NAFLD Controls Comparison Measure ERROR vs. ERROR


1 months

N Analyzed 49 24 <0.05
Crude or Adjusted Analysis Adj Adj
Mean Fructose Level 356 170
Fructose level 95% Confidence Interval nd (a bar graph was reported but not sure what was the range) nd (a bar graph was reported but not sure what was the range)
Comments


Quality Dimensions
Dimension Value Notes Comments
1) Is the case definition adequate? b
  • Comments Comments (
    0
    ) |
2) Representativeness of the cases b
  • Comments Comments (
    0
    ) |
3) Selection of controls b
  • Comments Comments (
    0
    ) |
4) Definition of controls a
  • Comments Comments (
    0
    ) |
5) Comparability of cases and controls on the basis of the design or analysis: age and sex a
  • Comments Comments (
    0
    ) |
6) Comparability of cases and controls on the basis of the design or analysis: anthropometrics a
  • Comments Comments (
    0
    ) |
7) Comparability of cases and controls on the basis of the design or analysis: nutrient and energy intake b
  • Comments Comments (
    0
    ) |
8) Ascertainment of exposure d
  • Comments Comments (
    0
    ) |
9) Same method of ascertainment for cases and controls a
  • Comments Comments (
    0
    ) |
10) Description of a validated method to quantify the amount, per type, of nutrients of interest c
  • Comments Comments (
    0
    ) |
11) Non-response rate c
  • Comments Comments (
    0
    ) |

Quality Rating
Guideline Used Overall Rating
High