Advanced Search

Study Preview



Study Title and Description

A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans.



Key Questions Addressed
2 What are the relationships between fructose consumption and indices of liver health?
  • Comments Comments (
    0
    ) |
4 Risk of Bias - Cohort, Case-Control, and Single Arm Studies
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans.
Author Lê KA., Faeh D., Stettler R., Ith M., Kreis R., Vermathen P., Boesch C., Ravussin E., Tappy L.
Country Department of Physiology, University of Lausanne, Lausanne, Switzerland.
Year 2006
Numbers Pubmed ID: 17158419
1181 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Fructose and NAFLD
Arms
Number Title Description Comments
1 Fructose
  • Comments Comments (
    0
    ) |

Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Single Arm Trial
  • Comments Comments (
    0
    ) |
Enrollment Years nd
  • Comments Comments (
    0
    ) |
Trial or Cohort Name nd
  • Comments Comments (
    0
    ) |
Funding Source Swiss National Science Foundation, Novartis Consumer Health Foundation
  • Comments Comments (
    0
    ) |
Inclusion Criteria -healthy -BMI between 19 and 25 -moderately physically active (<1 h/wk)
  • Comments Comments (
    0
    ) |
Exclusion Criteria -no medications -didn’t regularly consume alcohol or sugar-sweetened beverages
  • Comments Comments (
    0
    ) |
Location Switzerland
  • Comments Comments (
    0
    ) |
Counfounders No (Skip question #10)
  • Comments Comments (
    0
    ) |


Baseline Characteristics
Question Fructose Total Comments
AnswerFollow-up AnswerFollow-up
N Enrolled 7
  • Comments Comments (
    0
    ) |
N Analyzed 7
  • Comments Comments (
    0
    ) |
Mean (SD) Age, yrs 24.7 (1.3 SE)
  • Comments Comments (
    0
    ) |
Age range (IQR) nd
  • Comments Comments (
    0
    ) |
Male % 100%
  • Comments Comments (
    0
    ) |
Anthropometry data Body Weight Body weight 69.3 (SE 2.6)
  • Comments Comments (
    0
    ) |
Alcohol Intake didn’t regularly consume alcohol
  • Comments Comments (
    0
    ) |
Co-morbidity (other diseases/conditions) none
  • Comments Comments (
    0
    ) |
Other important baseline characteristics or baseline confounders nd
  • Comments Comments (
    0
    ) |
Background Diet Baseline diet
  • Comments Comments (
    0
    ) |
Instruction by a trained dietitian. 3-day diet record was used to verify adherence.
  • Comments Comments (
    0
    ) |
n/a
  • Comments Comments (
    0
    ) |
n/a
  • Comments Comments (
    0
    ) |
50% carbohydrates, 30% fat, and 15% protein. Subjects were further instructed to consume a minimal amount of either sucrose-sweetened or artificially sweetened drinks and food during this perios, with a resultant fructose consumption of <20 g/d.
  • Comments Comments (
    0
    ) |
Race/Ethnicity nd
  • Comments Comments (
    0
    ) |



Results & Comparisons


Results Data
Outcome: IHCL      Population: All Participants
Time Point Measure Fructose


0 N/A

N Analyzed 7
Unit mmol/kg
Baseline Value 5.9
Baseline Standard Deviation nd
Final Value 6.3
Final Standard Deviation nd
net difference +0.4
net difference 95% Confidence Interval nd
p value ns

Adverse Events
Arm or Total Title Description Comments
Fructose Not Reported
  • Comments Comments (
    0
    ) |
Total

Extraction Form: Cohort, Case Control, Single Arm Quality


Results & Comparisons


Results Data
Outcome: IHCL      Population: All Participants
Time Point Measure Fructose


0 N/A

N Analyzed 7
Unit mmol/kg
Baseline Value 5.9
Baseline Standard Deviation nd
Final Value 6.3
Final Standard Deviation nd
net difference +0.4
net difference 95% Confidence Interval nd
p value ns


Quality Dimensions
Dimension Value Notes Comments
1) Representativeness of the exposed cohort. b
  • Comments Comments (
    0
    ) |
2) Ascertainment of nutrient exposure b
  • Comments Comments (
    0
    ) |
3) Demonstration that outcome of interest was not present at start of the study a
  • Comments Comments (
    0
    ) |
4) Description of a validated method to quantify the amount, per type, of nutrient of interest b
  • Comments Comments (
    0
    ) |
5) Assessment of outcome d
  • Comments Comments (
    0
    ) |
6) Was follow up long enough for outcomes to occur? c
  • Comments Comments (
    0
    ) |
7) Adequacy of follow up of cohort a
  • Comments Comments (
    0
    ) |
8) Analytic control for confounding (ANY confounders other than age and sex) b
  • Comments Comments (
    0
    ) |
9) Analytic control for confounding: anthropomentrics b
  • Comments Comments (
    0
    ) |
10) Analytic control for confounding: other nutrients b
  • Comments Comments (
    0
    ) |
11) Power calculation to support sample size No
  • Comments Comments (
    0
    ) |

Quality Rating
Guideline Used Overall Rating
High