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Study Title and Description

Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans.



Key Questions Addressed
2 What are the relationships between fructose consumption and indices of liver health?
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3 Risk of Bias - RCTs and non-RCT
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Primary Publication Information
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TitleData
Title Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans.
Author Theytaz F., Noguchi Y., Egli L., Campos V., Buehler T., Hodson L., Patterson BW., Nishikata N., Kreis R., Mittendorfer B., Fielding B., Boesch C., Tappy L.
Country Department of Physiology, University of Lausanne, Lausanne, Switzerland.
Year 2012
Numbers Pubmed ID: 23034968

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Fructose and NAFLD
Arms
Number Title Description Comments
1 Fructose
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2 Healthy/Isocaloric diet
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Randomized Control Trial (crossover)
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Enrollment Years nd
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Trial or Cohort Name nd
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Funding Source grant from Swiss National Foundation for science and grant from Ajinomoto Co Inc
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Inclusion Criteria healthy, nonsmokers, nonobese. sedentary, no history of medications, no diabetes
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Exclusion Criteria none
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Location Switzerland
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Counfounders No (Skip question #10)
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Baseline Characteristics
Question Fructose Healthy/Isocaloric diet Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up
N Enrolled 9 9 9
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N Analyzed 9 9 9
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Mean (SD) Age, yrs 23.3 (0.9)
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Age range (IQR) nd
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Male % 100%
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Anthropometry data BMI 22.6 (0.5)
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Alcohol Intake nd
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Co-morbidity (other diseases/conditions) none
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Other important baseline characteristics or baseline confounders none
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Background Diet nd
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nd
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nd
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nd
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nd
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Race/Ethnicity nd
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Results & Comparisons


Results Data
Outcome: IHCL      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Healthy/Isocaloric diet Comparison Measure ERROR vs. ERROR


6 days

N Analyzed 9 9 N Analyzed 9
Mean 2.74 1.27 Mean Difference (Net) 1.47
Unit vol % squared vol % squared P-Value <0.05
Standard Error 0.55 0.31

Adverse Events
Arm or Total Title Description Comments

Extraction Form: Intervention Studies Quality


Results & Comparisons


Results Data
Outcome: IHCL      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Healthy/Isocaloric diet Comparison Measure ERROR vs. ERROR


6 days

N Analyzed 9 9 N Analyzed 9
Mean 2.74 1.27 Mean Difference (Net) 1.47
Unit vol % squared vol % squared P-Value <0.05
Standard Error 0.55 0.31


Quality Dimensions
Dimension Value Notes Comments
1) Was method of randomization adequate? [Yes, No, Unsure] Yes
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2) Was the treatment allocation concealed? Yes
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3) Was the patient blinded to the intervention? [Yes, No, Unsure] Yes
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4) Was the care provider blinded to the intervention? [Yes, No, Unsure] No
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5) Was the outcome assessor blinded to the intervention? [Yes, No, Unsure] No
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6) Was the dropout rate described and acceptable? [Yes, No, Unsure] Yes
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7) Analyzed in the group to which they were allocated? [Yes, No, Unsure] Yes
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8) Are reports of the study free of suggestion of selective outcome reporting? [Yes, No, Unsure] Yes
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9) Were the groups similar at baseline regarding the most important risk factors of NAFLD (e.g. comorbidity, background diet)? [Yes, No, Unsure] Yes
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10) Were co-interventions avoided or similar? [Yes, No, Unsure] Yes
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11) Was the compliance acceptable (greater than 80%) in all groups? [Yes, No, Unsure] Yes
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12) Was the timing of the outcome assessment similar in all groups? [Yes, No, Unsure] Yes
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13) Was the total fructose intake (including intervention dose and background fructose intake from diet) measured? [Yes, No, Unsure] Yes
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Quality Rating
Guideline Used Overall Rating
Low