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Study Title and Description

Evaluation of a rapid molecular screening approach for the detection of toxigenic Clostridium difficile in general and subsequent identification of the tcdC Δ117 mutation in human stools.



Key Questions Addressed
1 How do different methods for detection of toxigenic C. difficile to assist with diagnosis of CDI compare in their sensitivity, specificity, and predictive values? a. Overall? b. Do performance measures vary with sample characteristics? c. Does testing strategy impact patient health or health system outcomes?
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2 What are effective prevention strategies? a. What is the effectiveness of current prevention strategies? b. What are the harms associated with prevention strategies? c. How sustainable are prevention practices in health care (outpatient, hospital inpatient, extended care) and community settings?
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3 What is the comparative effectiveness and harms of different antibiotic treatments? a. Does effectiveness vary by disease severity?
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4 What are the effectiveness and harms of other interventions? a. Overall b. In patients with relapse/recurrent CDI.
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Primary Publication Information
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TitleData
Title Evaluation of a rapid molecular screening approach for the detection of toxigenic Clostridium difficile in general and subsequent identification of the tcdC Δ117 mutation in human stools.
Author de Boer RF., Wijma JJ., Schuurman T., Moedt J., Dijk-Alberts BG., Ott A., Kooistra-Smid AM., van Duynhoven YT.
Country Department of Research & Development, Laboratory for Infectious Diseases, Groningen, The Netherlands. r.de.boer@infectielab.nl
Year 2010
Numbers Pubmed ID: 20674616

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Detection, prevention, treatments, and efficacy and harms of interventions for C. difficile


Results & Comparisons

No Results found.