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Study Title and Description

Clinical and laboratory evaluation of a real-time PCR for Clostridium difficile toxin A and B genes.



Key Questions Addressed
1 How do different methods for detection of toxigenic C. difficile to assist with diagnosis of CDI compare in their sensitivity, specificity, and predictive values? a. Overall? b. Do performance measures vary with sample characteristics? c. Does testing strategy impact patient health or health system outcomes?
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2 What are effective prevention strategies? a. What is the effectiveness of current prevention strategies? b. What are the harms associated with prevention strategies? c. How sustainable are prevention practices in health care (outpatient, hospital inpatient, extended care) and community settings?
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3 What is the comparative effectiveness and harms of different antibiotic treatments? a. Does effectiveness vary by disease severity?
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4 What are the effectiveness and harms of other interventions? a. Overall b. In patients with relapse/recurrent CDI.
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Primary Publication Information
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TitleData
Title Clinical and laboratory evaluation of a real-time PCR for Clostridium difficile toxin A and B genes.
Author de Jong E., de Jong AS., Bartels CJ., van der Rijt-van den Biggelaar C., Melchers WJ., Sturm PD.
Country Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, Netherlands.
Year 2012
Numbers Pubmed ID: 22327373

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Detection, prevention, treatments, and efficacy and harms of interventions for C. difficile


Results & Comparisons

No Results found.