Study Title and Description
Diagnosing toxigenic Clostridium difficile: new confidence bounds show culturing increases sensitivity of the toxin A/B enzyme immunoassay and refute gold standards.
Key Questions Addressed
|1||How do different methods for detection of toxigenic C. difficile to assist with diagnosis of CDI compare in their sensitivity, specificity, and predictive values? a. Overall? b. Do performance measures vary with sample characteristics? c. Does testing strategy impact patient health or health system outcomes?|
|2||What are effective prevention strategies? a. What is the effectiveness of current prevention strategies? b. What are the harms associated with prevention strategies? c. How sustainable are prevention practices in health care (outpatient, hospital inpatient, extended care) and community settings?|
|3||What is the comparative effectiveness and harms of different antibiotic treatments? a. Does effectiveness vary by disease severity?|
|4||What are the effectiveness and harms of other interventions? a. Overall b. In patients with relapse/recurrent CDI.|
Primary Publication Information
|Title||Diagnosing toxigenic Clostridium difficile: new confidence bounds show culturing increases sensitivity of the toxin A/B enzyme immunoassay and refute gold standards.|
|Author||Mattner F., Winterfeld I., Mattner L.|
|Country||Institut für Hygiene, Universitätsklinikum der privaten Universität Witten-Herdecke, Campus Köln-Merheim, Köln, Germany. email@example.com|
Pubmed ID: 22404319
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Detection, prevention, treatments, and efficacy and harms of interventions for C. difficile
Results & Comparisons
No Results found.