Study Title and Description
Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection.
Key Questions Addressed
|1||How do different methods for detection of toxigenic C. difficile to assist with diagnosis of CDI compare in their sensitivity, specificity, and predictive values? a. Overall? b. Do performance measures vary with sample characteristics? c. Does testing strategy impact patient health or health system outcomes?|
|2||What are effective prevention strategies? a. What is the effectiveness of current prevention strategies? b. What are the harms associated with prevention strategies? c. How sustainable are prevention practices in health care (outpatient, hospital inpatient, extended care) and community settings?|
|3||What is the comparative effectiveness and harms of different antibiotic treatments? a. Does effectiveness vary by disease severity?|
|4||What are the effectiveness and harms of other interventions? a. Overall b. In patients with relapse/recurrent CDI.|
Primary Publication Information
|Title||Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection.|
|Author||Planche TD., Davies KA., Coen PG., Finney JM., Monahan IM., Morris KA., O'Connor L., Oakley SJ., Pope CF., Wren MW., Shetty NP., Crook DW., Wilcox MH.|
|Country||Centre for Infection and Immunity, Division of Clinical Medicine, St George's, University of London, London, UK; Department of Medical Microbiology, St George's Healthcare NHS Trust, London, UK.|
Pubmed ID: 24007915
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Detection, prevention, treatments, and efficacy and harms of interventions for C. difficile
Results & Comparisons
No Results found.