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Project: Systematic Review of Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin

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Title and Description

Title Systematic Review of Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin
Description
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Contributor(s) Aaron Drucker, M.D. Gaelen P. Adam, M.L.I.S. Valerie Langberg, M.S. Abhilash Gazula, M.P.H. Bryant Smith, M.P.H. Farah Moustafa, M.D. Martin A. Weinstock, M.D. Ph.D. Thomas A. Trikalinos, M.D.
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Methodology We conducted literature searches in MEDLINE®, the Cochrane Central Trials Registry and Cochrane Database of Systematic Reviews, and Embase® up to March 2017. We also perused the reference lists of published relevant clinical practice guidelines and systematic reviews. We recorded information on recurrence, histologic clearance, clinical clearance, patient- or observer-rated cosmetic outcomes, adverse effects, quality of life, costs and resources, mental health, patient satisfaction, and mortality. We estimated intervention effects (differences in outcomes between treatments) and the mean frequency of the outcome with each treatment using network meta-analyses.
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DOI
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Funding Source This report is based on research conducted by the Brown Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2015-00002-I).
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Notes Report PMID 29533571 Data was entered into this project prospectively.
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Key Questions

1 Comparison of interventions
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Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Comparative studies Gaelen Adam 1


Associated Studies (each link opens a new tab)

Title Author Year
Fractionated 5-aminolaevulinic acid-photodynamic therapy vs. surgical excision in the treatment of nodular basal cell carcinoma: results of a randomized controlled trial. Mosterd K., Thissen MR., Nelemans P., Kelleners-Smeets NW., Janssen RL., Broekhof KG., Neumann HA., Steijlen PM., Kuijpers DI. 2008
Comparison of imiquimod 5% cream versus radiotherapy as treatment for eyelid basal cell carcinoma. Garcia-Martin E., Gil-Arribas LM., Idoipe M., Alfaro J., Pueyo V., Pablo LE., Fernandez FJ. 2011
A phase III, randomized, open label study to evaluate the safety and efficacy of imiquimod 5% cream applied thrice weekly for 8 and 12 weeks in the treatment of low-risk nodular basal cell carcinoma. Eigentler TK., Kamin A., Weide BM., Breuninger H., Caroli UM., Möhrle M., Radny P., Garbe C. 2007
The effect of intralesional 5-Fluorouracil Therapeutic Implant (MPI 5003) for treatment of basal cell carcinoma Orenberg EK et al 1992
Imiquimod 5% cream as pretreatment of Mohs micrographic surgery for nodular basal cell carcinoma in the face: a prospective randomized controlled study. van der Geer S., Martens J., van Roij J., Brand E., Ostertag JU., Verhaegh ME., Neumann HA., Krekels GA. 2012
Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study. Avril MF., Auperin A., Margulis A., Gerbaulet A., Duvillard P., Benhamou E., Guillaume JC., Chalon R., Petit JY., Sancho-Garnier H., Prade M., Bouzy J., Chassagne D. 1997
Nonsurgical treatment of basal cell carcinomas with intralesional 5-fluorouracil/epinephrine injectable gel. Miller BH., Shavin JS., Cognetta A., Taylor RJ., Salasche S., Korey A., Orenberg EK. 1997
Cryotherapy of basal cell lesions. Allen ED., McGill JI., Hall VL., Bodkin RE., Macdonald H., Buchanan RB., White JE., Leppard BJ., Goodwin PS., Fraser J. 1979
The effect of intralesional interferon gamma on basal cell carcinomas. Edwards L., Whiting D., Rogers D., Luck K., Smiles KA. 1990
Intralesional interferon therapy for basal cell carcinoma. Cornell RC., Greenway HT., Tucker SB., Edwards L., Ashworth S., Vance JC., Tanner DJ., Taylor EL., Smiles KA., Peets EA. 1990
Treatment of basal-cell carcinoma: comparison of radiotherapy and cryotherapy. Hall VL., Leppard BJ., McGill J., Kesseler ME., White JE., Goodwin P. 1986
The effect of an intralesional sustained-release formulation of interferon alfa-2b on basal cell carcinomas. Edwards L., Tucker SB., Perednia D., Smiles KA., Taylor EL., Tanner DJ., Peets E. 1990
Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease. Morton CA., Whitehurst C., Moseley H., McColl JH., Moore JV., Mackie RM. 1996
Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream. Beutner KR., Geisse JK., Helman D., Fox TL., Ginkel A., Owens ML. 1999
Cosmetic results of cryosurgery versus surgical excision for primary uncomplicated basal cell carcinomas of the head and neck. Thissen MR., Nieman FH., Ideler AH., Berretty PJ., Neumann HA. 2000
Photodynamic therapy vs. cryosurgery of basal cell carcinomas: results of a phase III clinical trial. Wang I., Bendsoe N., Klinteberg CA., Enejder AM., Andersson-Engels S., Svanberg S., Svanberg K. 2001
Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial. Marks R., Gebauer K., Shumack S., Amies M., Bryden J., Fox TL., Owens ML. 2001
Surgical excision versus curettage plus cryosurgery in the treatment of basal cell carcinoma. Kuijpers DI., Thissen MR., Berretty PJ., Ideler FH., Nelemans PJ., Neumann MH. 2007
Efficacy of excisional surgery, curettage and combined curettage and electrodessication in treatment of basal cell carcinoma Salmanpoor R. et al. 2012
A randomized trial comparing methyl aminolaevulinate photodynamic therapy with and without Er:YAG ablative fractional laser treatment in Asian patients with lower extremity Bowen disease: results from a 12-month follow-up. Ko DY., Kim KH., Song KH. 2014
Surgical excision versus Mohs; micrographic surgery for primary and recurrent basal-cell carcinoma of the face: a prospective randomised controlled trial with 5-years; follow-up. Mosterd K., Krekels GA., Nieman FH., Ostertag JU., Essers BA., Dirksen CD., Steijlen PM., Vermeulen A., Neumann H., Kelleners-Smeets NW. 2008
Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen's disease. Salim A., Leman JA., McColl JH., Chapman R., Morton CA. 2003
Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial. Arits AH., Mosterd K., Essers BA., Spoorenberg E., Sommer A., De Rooij MJ., van Pelt HP., Quaedvlieg PJ., Krekels GA., van Neer PA., Rijzewijk JJ., van Geest AJ., Steijlen PM., Nelemans PJ., Kelleners-Smeets NW. 2013
Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion. Sterry W., Ruzicka T., Herrera E., Takwale A., Bichel J., Andres K., Ding L., Thissen MR. 2002
Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial. Rhodes LE., de Rie M., Enström Y., Groves R., Morken T., Goulden V., Wong GA., Grob JJ., Varma S., Wolf P. 2004
Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma: comparison of dosing regimens - 12 Week Study Shumack S., Robinson J., Kossard S., Golitz L., Greenway H., Schroeter A., Andres K., Amies M., Owens M. 2002
Efficacy of topical 5% imiquimod cream for the treatment of nodular basal cell carcinoma: comparison of dosing regimens - 6 Week Study Shumack S., Robinson J., Kossard S., Golitz L., Greenway H., Schroeter A., Andres K., Amies M., Owens M. 2002
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: a double-blind, randomized, vehicle-controlled study. Geisse JK., Rich P., Pandya A., Gross K., Andres K., Ginkel A., Owens M. 2002
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies. Geisse J., Caro I., Lindholm J., Golitz L., Stampone P., Owens M. 2004
5% imiquimod cream and reflectance-mode confocal microscopy as adjunct modalities to Mohs micrographic surgery for treatment of basal cell carcinoma. Torres A., Niemeyer A., Berkes B., Marra D., Schanbacher C., González S., Owens M., Morgan B. 2004
Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or Fluorouracil for treatment of squamous cell carcinoma in situ: Results of a multicenter randomized trial. Morton C., Horn M., Leman J., Tack B., Bedane C., Tjioe M., Ibbotson S., Khemis A., Wolf P. 2006
Photodynamic therapy in combination with CO2 laser for the treatment of Bowen's disease. Cai H., Wang YX., Zheng JC., Sun P., Yang ZY., Li YL., Liu XY., Li Q., Liu W. 2015
Comparison of aminolevulinic acid (ALA)-thermogel-PDT with methyl-ALA-thermogel-PDT in basal cell carcinoma. Schleier P., Berndt A., Kolossa S., Zenk W., Hyckel P., Schultze-Mosgau S. 2007
PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: results of a randomized phase IIa trial. Siller G., Rosen R., Freeman M., Welburn P., Katsamas J., Ogbourne SM. 2010
Treatment of basal cell carcinoma with surgical excision and perilesional interferon-α. Wettstein R., Erba P., Itin P., Schaefer DJ., Kalbermatten DF. 2013
Higher recurrence rates of head and neck nodular basal cell carcinoma treated with topical photodynamic therapy (MAL-PDT) compared to surgical excision: A randomized controlled study Abbade, Luciana; Tatiana Gige; Viviany Amaral; Sabrina Aquino; Helio Miot 2015
Imiquimod 5% cream as adjunctive therapy for primary, solitary, nodular nasal basal cell carcinomas before Mohs micrographic surgery: a randomized, double blind, vehicle-controlled study. Butler DF., Parekh PK., Lenis A. 2009
Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial. Migden MR., Guminski A., Gutzmer R., Dirix L., Lewis KD., Combemale P., Herd RM., Kudchadkar R., Trefzer U., Gogov S., Pallaud C., Yi T., Mone M., Kaatz M., Loquai C., Stratigos AJ., Schulze HJ., Plummer R., Chang AL., Cornélis F., Lear JT., Sellami D., Dummer R. 2015
Effectiveness of a 595-nm pulsed dye laser for the treatment of basal cell carcinoma using 1 stacked-pulse session Eimpunth S, Oganesyan G, Hamman MS, Lee R, Jiang SI, Kim SS, 2014
Single treatment of non-melanoma skin cancers using a pulsed-dye laser with stacked pulses. Tran HT., Lee RA., Oganesyan G., Jiang SB. 2012
The effect of topical diclofenac 3% and calcitriol 3 μg/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): A phase II, randomized controlled trial. Brinkhuizen T., Frencken KJ., Nelemans PJ., Hoff ML., Kelleners-Smeets NW., Zur Hausen A., van der Horst MP., Rennspiess D., Winnepenninckx VJ., van Steensel MA., Mosterd K. 2016
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled phase III study in Europe. Schulze HJ., Cribier B., Requena L., Reifenberger J., Ferrándiz C., Garcia Diez A., Tebbs V., McRae S. 2005
Pilot study of imiquimod 5% cream as adjunctive therapy to curettage and electrodesiccation for nodular basal cell carcinoma. Spencer JM. 2006
Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen's disease): a randomized, double-blind, placebo-controlled trial. Patel GK., Goodwin R., Chawla M., Laidler P., Price PE., Finlay AY., Motley RJ. 2006
A randomized study of minimal curettage followed by topical photodynamic therapy compared with surgical excision for low-risk nodular basal cell carcinoma. Berroeta L., Clark C., Dawe RS., Ibbotson SH., Fleming CJ. 2007
A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8-20 mm), with a 12-month follow-up. Szeimies RM., Ibbotson S., Murrell DF., Rubel D., Frambach Y., de Berker D., Dummer R., Kerrouche N., Villemagne H. 2008
Topical methyl aminolaevulinate photodynamic therapy versus cryotherapy for superficial basal cell carcinoma: a 5 year randomized trial. Basset-Seguin N., Ibbotson SH., Emtestam L., Tarstedt M., Morton C., Maroti M., Calzavara-Pinton P., Varma S., Roelandts R., Wolf P. 2008
Photodynamic therapy with methyl aminolevulinate for primary nodular basal cell carcinoma: results of two randomized studies. Foley P., Freeman M., Menter A., Siller G., El-Azhary RA., Gebauer K., Lowe NJ., Jarratt MT., Murrell DF., Rich P., Pariser DM., Oseroff AR., Barnetson R., Anderson C., Kossard S., Gibson LE., Tope WD. 2009
Er:YAG ablative fractional laser-primed photodynamic therapy with methyl aminolevulinate as an alternative treatment option for patients with thin nodular basal cell carcinoma: 12-month follow-up results of a randomized, prospective, comparative trial. Choi SH., Kim KH., Song KH. 2016
Similar effectiveness of methyl aminolevulinate and 5-aminolevulinate in topical photodynamic therapy for nodular basal cell carcinoma. Kuijpers DI., Thissen MR., Thissen CA., Neumann MH. 2006
Photodynamic Therapy Followed by Mohs Micrographic Surgery Compared to Mohs Micrographic Surgery Alone for the Treatment of Basal Cell Carcinoma: Results of a Pilot Single-Blinded Randomised Controlled Trial. Al-Niaimi F., Sheth N., Kurwa HA., Mallipeddi R. 2015
Fractional laser-mediated photodynamic therapy of high-risk basal cell carcinomas--a randomized clinical trial. Haak CS., Togsverd-Bo K., Thaysen-Petersen D., Wulf HC., Paasch U., Anderson RR., Haedersdal M. 2015
Comparison of the effects of intralesional interferon alfa-2a, 2b and the combination of 2a and 2b in the treatment of basal cell carcinoma. Alpsoy E., Yilmaz E., Başaran E., Yazar S. 1996
Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial. Bath-Hextall F., Ozolins M., Armstrong SJ., Colver GB., Perkins W., Miller PS., Williams HC. 2014
Tumor recurrence 5 years after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma. Chren MM., Linos E., Torres JS., Stuart SE., Parvataneni R., Boscardin WJ. 2013
Factors affecting the recurrence rate of basal cell carcinoma. Bøgelund FS., Philipsen PA., Gniadecki R. 2007
Evaluation of superficial basal cell carcinomas after treatment with imiquimod 5% cream or vehicle for apoptosis and lymphocyte phenotyping. Sullivan TP., Dearaujo T., Vincek V., Berman B. 2003
Effect of imiquimod as compared with surgery on the cancerization field in basal cell carcinoma. Graells J., Ojeda RM., García-Cruz A. 2014
Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC): Comparison between 2 different schedules. Pampena R., Palmieri T., Kyrgidis A., Ramundo D., Iotti C., Lallas A., Moscarella E., Borsari S., Argenziano G., Longo C. 2016
A phase II, multicenter, open-label, 3-cohort trial evaluating the efficacy and safety of vismodegib in operable basal cell carcinoma. Sofen H., Gross KG., Goldberg LH., Sharata H., Hamilton TK., Egbert B., Lyons B., Hou J., Caro I. 2015
Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: randomized studies comparing low-frequency dosing with and without occlusion. Sterry W., Ruzicka T., Herrera E., Takwale A., Bichel J., Andres K., Ding L., Thissen MR. 2002
Fractional carbon dioxide laser improves nodular basal cell carcinoma treatment with photodynamic therapy with methyl 5-aminolevulinate. Lippert J., Smucler R., Vlk M. 2013
Electronic brachytherapy for superficial and nodular basal cell carcinoma: a report of two prospective pilot trials using different doses. Ballester-Sánchez R., Pons-Llanas O., Candela-Juan C., Celada-Álvarez FJ., Barker CA., Tormo-Micó A., Pérez-Calatayud J., Botella-Estrada R. 2016
Photodynamic therapy using topical 5-aminolaevulinic acid vs. surgery for basal cell carcinoma Cosgarea R, Susan M, Crisan M, Senila S 2012
The effect of 595 nm pulsed dye laser on superficial and nodular basal cell carcinomas. Shah SM., Konnikov N., Duncan LM., Tannous ZS. 2009
Comparison of cryotherapy with curettage in the treatment of Bowen's disease: a prospective study. Ahmed I., Berth-Jones J., Charles-Holmes S., O'Callaghan CJ., Ilchyshyn A. 2000
Fee comparisons of treatments for nonmelanoma skin cancer in a private practice academic setting. Wilson LS., Pregenzer M., Basu R., Bertenthal D., Torres J., Asgari M., Chren MM. 2012
Single treatment of low-risk basal cell carcinomas with pulsed dye laser-mediated photodynamic therapy (PDL-PDT) compared with photodynamic therapy (PDT): A controlled, investigator-blinded, intra-individual prospective study. Čarija A., Puizina-Ivić N., Vuković D., Mirić Kovačević L., Čapkun V. 2016
Effect of Methyl Aminolevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: A Randomized Clinical Trial. Choi SH., Kim KH., Song KH. 2017




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The data contained in this project are distributed under the terms of the Creative Commons Attribution-NonCommerical license, which permits the use, dissemination, and reproduction in any medium, provided the original work is properly cited, and that the use is non-commercial and otherwise in compliance with the license. See: https://creativecommons.org/licenses/by-nc/3.0/