Advanced Search

Study Preview



Study Title and Description

Cryotherapy of basal cell lesions.



Key Questions Addressed
1 Comparison of interventions
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Cryotherapy of basal cell lesions.
Author Allen ED., McGill JI., Hall VL., Bodkin RE., Macdonald H., Buchanan RB., White JE., Leppard BJ., Goodwin PS., Fraser J.
Country -- Not Found --
Year 1979
Numbers Pubmed ID: 298425

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Comparative studies
Arms
Number Title Description Comments
1 cryotherapy
  • Comments Comments (
    0
    ) |
2 radiotherapy
  • Comments Comments (
    0
    ) |

Design Details
Question... Follow Up Answer Follow-up Answer
Publication or abstract? Publication
  • Comments Comments (
    0
    ) |
Study design RCT
  • Comments Comments (
    0
    ) |
Multicenter etc. Single center
  • Comments Comments (
    0
    ) |
Country/Region UK
  • Comments Comments (
    0
    ) |
Funding NR
  • Comments Comments (
    0
    ) |
Inclusion criteria Patients with basal cell carcinoma anywhere in the body
  • Comments Comments (
    0
    ) |
Exclusion criteria less than 18 years of age; previous deep x-ray treatment or cryotherapy; lesion near the eye when the other eye sees less than 6/18.
  • Comments Comments (
    0
    ) |
N Enrolled/Randomized/Analyzed 31
  • Comments Comments (
    0
    ) |
31
  • Comments Comments (
    0
    ) |
31
  • Comments Comments (
    0
    ) |
Notes/Comments
  • Comments Comments (
    0
    ) |
Method of diagnosis ... Describe Other ... NR
  • Comments Comments (
    0
    ) |
Preoperative assessment of clinical size of the tumor ... not reported ...
  • Comments Comments (
    0
    ) |
Percent non-primary (recurrent) NR
  • Comments Comments (
    0
    ) |
Secondary size assessment
  • Comments Comments (
    0
    ) |


Baseline Characteristics
Question cryotherapy radiotherapy Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up
Continuous baselines NR
  • Comments Comments (
    0
    ) |
NR
  • Comments Comments (
    0
    ) |
NR
  • Comments Comments (
    0
    ) |
NR
  • Comments Comments (
    0
    ) |
Gender/Racial descent No data entered.
Lesion location No data entered.
Skin type (Fitzpatrick score) No data entered.
Number of lesions per patient NR NR NR
  • Comments Comments (
    0
    ) |
Previous treatments No data entered.
Immunocompromized status No data entered.
Number of patients/lesions 15 16 31
  • Comments Comments (
    0
    ) |
15 16 31
  • Comments Comments (
    0
    ) |
NR NR 31
  • Comments Comments (
    0
    ) |
15 16
  • Comments Comments (
    0
    ) |
Lesion extent number of people 15 16
  • Comments Comments (
    0
    ) |
Lesion extent number of people No data entered.



Results & Comparisons


Results Data
Outcome: Lack of clinical clearance      Population: All Participants
Time Point Measure cryotherapy radiotherapy


6 months

N Analyzed 15 16
Counts 1 0


Quality Dimensions
Dimension Value Notes Comments
RCT:....Adequate generation of a randomized sequence reported Yes "subjects randomly assigned in a coded, controlled trial."
  • Comments Comments (
    0
    ) |
RCT:....Adequate allocation concealment reported Yes "randomly coded allocation of treatment"
  • Comments Comments (
    0
    ) |
RCT:....Adequate blinding of PATIENTS reported Yes Subjects could not be blinded to treatment allocation (Cryotherapy vs. Radiotherapy)
  • Comments Comments (
    0
    ) |
RCT:....Adequate blinding of PROVIDERS reported No Data No mention is made of blinding providers; Review Authors do not discuss whether this would impact the outcome.
  • Comments Comments (
    0
    ) |
ALL....Adequate blinding of OUTCOME ASSESSORS reported No Data No mention is made of blinding outcome assessors; Review Authors do not discuss whether this would impact the outcome.
  • Comments Comments (
    0
    ) |
ALL.....Incomplete results data: are more than 20% missing for any eligible outcome in any group? No Data Only Recurrence was reported, but it was reported completely for both arms of the trial.
  • Comments Comments (
    0
    ) |
ALL.....Selective Reporting (judgement - put directly into notes field). Low RoB Outcome of interest, recurrence, was reported by arm.
  • Comments Comments (
    0
    ) |
RCT.....Is the treatment effect by Intention to treat? No Data No dropouts reported.
  • Comments Comments (
    0
    ) |
ALL....Group similarity at baseline. No Data No Table 1 / patient characteristics reported.
  • Comments Comments (
    0
    ) |
ALL....Additional Bias: Bias due to problems not covered elsewhere. (judgement - put directly into notes field) No
  • Comments Comments (
    0
    ) |
ALL (with AE results)....Were reported adverse events (of interest) precisely defined No Data No Adverse Events were reported
  • Comments Comments (
    0
    ) |
Overall, by outcome (judgement - put directly into notes field) No High
  • Comments Comments (
    0
    ) |
ALL.....Incomplete results data: Is there differential missingness (more than 20%) between arms for any eligible outcome? No Data See above
  • Comments Comments (
    0
    ) |

Quality Rating
Guideline Used Overall Rating