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Study Title and Description

Treatment of basal-cell carcinoma: comparison of radiotherapy and cryotherapy.



Key Questions Addressed
1 Comparison of interventions
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Primary Publication Information
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TitleData
Title Treatment of basal-cell carcinoma: comparison of radiotherapy and cryotherapy.
Author Hall VL., Leppard BJ., McGill J., Kesseler ME., White JE., Goodwin P.
Country -- Not Found --
Year 1986
Numbers Pubmed ID: 3514075

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Comparative studies
Arms
Number Title Description Comments
1 Radiotherapy
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2 Cryotherapy
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Design Details
Question... Follow Up Answer Follow-up Answer
Publication or abstract? Publication
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Study design RCT
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Multicenter etc. Single center
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Country/Region UK
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Funding NR
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Inclusion criteria Basal-cell carcinoma proven by biopsy, and who were considered suitable for treatment with radiotherapy
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Exclusion criteria Recurrent tumors, location on nose or pinna, where electrons were considered Tx of choice, lesion near eye and vision in contralateral eye <6/18
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N Enrolled/Randomized/Analyzed 105
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105
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93
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Notes/Comments
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Method of diagnosis ... Describe Biopsy/pathologic confirmation ... "Proven by biopsy"
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Preoperative assessment of clinical size of the tumor ... not reported ...
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Percent non-primary (recurrent) 0
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Secondary size assessment
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Baseline Characteristics
Question Radiotherapy Cryotherapy Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up
Continuous baselines 19 <1 cm, 25 1-2 cm, 5 >2 cm 19 <1 cm, 23 1-2 cm, 2 >2 cm
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Gender/Racial descent No data entered.
Lesion location 40 30
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FACE AND NECK FACE AND NECK
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3 8
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6 8
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TRUNK (neck elsewhere) TRUNK (neck elsewhere)
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Skin type (Fitzpatrick score) No data entered.
Number of lesions per patient No data entered.
Previous treatments No data entered.
Immunocompromized status No data entered.
Number of patients/lesions 49 44 105
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N/A
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12
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5 died, 2 refused to attend follow-up, 5 lost to follow-up
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93
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Lesion extent number of people 49 44
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Lesion extent number of people No data entered.



Results & Comparisons


Results Data
Outcome: Recurrence or relapse      Population: All Participants
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 49 44
Counts 2 17


2 years

N Analyzed 49 44
Counts 2 17
Outcome: Recurrence or relapse      Population: Face and neck
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 40 30
Counts 2 12


2 years

N Analyzed 40 30
Counts 2 12
Outcome: Recurrence or relapse      Population: Eyelids
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 3 6
Counts 0 3


2 years

N Analyzed 3 6
Counts 0 3
Outcome: Recurrence or relapse      Population: Trunk
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 6 8
Counts 0 2


2 years

N Analyzed 6 8
Counts 0 2
Outcome: Recurrence or relapse      Population: <1 cm
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 19 19
Counts 0 6


2 years

N Analyzed 19 19
Counts 0 6
Outcome: Recurrence or relapse      Population: 1-2 cm
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 25 23
Counts 2 9


2 years

N Analyzed 25 23
Counts 2 9
Outcome: Recurrence or relapse      Population: >2 cm
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 5 2
Counts 0 2


2 years

N Analyzed 5 2
Counts 0 2
Outcome: Adverse events: other      Population: All Participants
Time Point Measure Radiotherapy Cryotherapy


n/a N/A

N Analyzed 49 44
Counts 1 1
Outcome: Cosmetic outcome (continuous)      Population: All Participants
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 49 44
Mean 0.94 0.88
SD
SE
Outcome: Cosmetic outcome (continuous)      Population: All Participants
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 49 44
Mean 0.31 0.54
SD
SE
Outcome: Cosmetic outcome (continuous)      Population: All Participants
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 49 44
Mean 1.00 1.03
SD
SE
Outcome: Cosmetic outcome (continuous)      Population: All Participants
Time Point Measure Radiotherapy Cryotherapy


1 years

N Analyzed 49 44
Mean 1.35 1.43
SD
SE


Quality Dimensions
Dimension Value Notes Comments
RCT:....Adequate generation of a randomized sequence reported No Not mentioned how randomized
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RCT:....Adequate allocation concealment reported No Not mentioned
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RCT:....Adequate blinding of PATIENTS reported No Not possible to blind
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RCT:....Adequate blinding of PROVIDERS reported No Not possible to blind
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ALL....Adequate blinding of OUTCOME ASSESSORS reported No Not mentioned
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ALL.....Incomplete results data: are more than 20% missing for any eligible outcome in any group? Unsure Only gives dropouts for whole study not per group
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ALL.....Selective Reporting (judgement - put directly into notes field). No
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RCT.....Is the treatment effect by Intention to treat? No Only analyzed patients with follow-up data
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ALL....Group similarity at baseline. No Difference in size and location
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ALL....Additional Bias: Bias due to problems not covered elsewhere. (judgement - put directly into notes field) No
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ALL (with AE results)....Were reported adverse events (of interest) precisely defined No
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Overall, by outcome (judgement - put directly into notes field) Unsure Differential missingness not reported
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ALL.....Incomplete results data: Is there differential missingness (more than 20%) between arms for any eligible outcome? No Data Only gives dropouts for whole study not per group
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Quality Rating
No quality rating data was found.