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Study Title and Description

Comparison of the effects of intralesional interferon alfa-2a, 2b and the combination of 2a and 2b in the treatment of basal cell carcinoma.



Key Questions Addressed
1 Comparison of interventions
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Primary Publication Information
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TitleData
Title Comparison of the effects of intralesional interferon alfa-2a, 2b and the combination of 2a and 2b in the treatment of basal cell carcinoma.
Author Alpsoy E., Yilmaz E., Ba┼čaran E., Yazar S.
Country Department of Dermatology, Akdeniz University Medical Faculty, Antalya, Turkey.
Year 1996
Numbers Pubmed ID: 8708151

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Comparative studies
Arms
Number Title Description Comments
1 IFN alfa-2a
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2 IFN alfa-2b
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3 IFN alfa-2a + IFN alfa-2b
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Design Details
Question... Follow Up Answer Follow-up Answer
Publication or abstract? Publication
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Study design RCT
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Multicenter etc. Unclear
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Country/Region Turkey
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Funding NR
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Inclusion criteria adults with histologically confirmed BCC
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Exclusion criteria recurrent lesions, genetic or nevoid conditions, or lesions with deep tissue involvement
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N Enrolled/Randomized/Analyzed 45
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45
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45
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Notes/Comments
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Method of diagnosis ... Describe Biopsy/pathologic confirmation ... histologically confirmed BCC
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Preoperative assessment of clinical size of the tumor ... not reported ...
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Percent non-primary (recurrent) 0
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Secondary size assessment
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Baseline Characteristics
Question IFN alfa-2a IFN alfa-2b IFN alfa-2a + IFN alfa-2b Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up AnswerFollow-up
Continuous baselines 58.7 63.6 60.3
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48, 73 38, 70 39, 74
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2.05 cm2 1.82 cm2 1.9 cm2
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0.5, 8.75 cm2 0.6, 8.2 cm2 0.5, 8.9 cm2
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Gender/Racial descent 8 8 6
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53% 53% 40%
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Lesion location 14 14 14
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93 93 93
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1 1 1
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7 7 7
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trunk trunk trunk
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chantus (eyelid) 4 (27%) nose 2 (13%) zygoma 4 (27%) forehead 2 (13%) cheek 2 (13%) chantus (eyelid) 3 (20%) nose 1 (7%) zygoma 3 (20%) forehead 3 (20%) cheek 4 (27%) chantus (eyelid) 3 (20%) nose 2 (13%) zygoma 4 (27%) forehead 2 (13%) cheek 3 (20%)
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Skin type (Fitzpatrick score) No data entered.
Number of lesions per patient No data entered.
Previous treatments No data entered.
Immunocompromized status No data entered.
Number of patients/lesions 15 15 15
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15 15 15
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15 15 15
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Lesion extent number of people 1 2 2
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12 11 11
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1 1 1
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Morphealike Morphealike Morphealike
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Lesion extent number of people No data entered.



Results & Comparisons


Results Data
Outcome: Lack of histological clearance      Population: All Participants
Time Point Measure IFN alfa-2a IFN alfa-2b IFN alfa-2a + IFN alfa-2b


8 weeks

N Analyzed 15 15 15
Counts 5 5 4
Outcome: Lack of histological clearance      Population: Nodular
Time Point Measure IFN alfa-2a IFN alfa-2b IFN alfa-2a + IFN alfa-2b


8 weeks

N Analyzed 12 11 11
Counts 4 4 2
Outcome: Lack of histological clearance      Population: Superficial
Time Point Measure IFN alfa-2a IFN alfa-2b IFN alfa-2a + IFN alfa-2b


8 weeks

N Analyzed 1 2 2
Counts 1 1 1
Outcome: Lack of histological clearance      Population: Morphealike
Time Point Measure IFN alfa-2a IFN alfa-2b IFN alfa-2a + IFN alfa-2b


8 weeks

N Analyzed 2 2 2
Counts 0 0 1
Outcome: Recurrence or relapse      Population: All Participants
Time Point Measure IFN alfa-2a IFN alfa-2b IFN alfa-2a + IFN alfa-2b


6-24 months

N Analyzed 15 15 15
Counts 0 0 0


Quality Dimensions
Dimension Value Notes Comments
RCT:....Adequate generation of a randomized sequence reported Unsure
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RCT:....Adequate allocation concealment reported Unsure
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RCT:....Adequate blinding of PATIENTS reported Unsure
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RCT:....Adequate blinding of PROVIDERS reported Unsure
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ALL....Adequate blinding of OUTCOME ASSESSORS reported Unsure
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ALL.....Incomplete results data: are more than 20% missing for any eligible outcome in any group? No
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ALL.....Selective Reporting (judgement - put directly into notes field).
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RCT.....Is the treatment effect by Intention to treat? Yes
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ALL....Group similarity at baseline. Yes
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ALL....Additional Bias: Bias due to problems not covered elsewhere. (judgement - put directly into notes field)
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ALL (with AE results)....Were reported adverse events (of interest) precisely defined Yes
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Overall, by outcome (judgement - put directly into notes field) high
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ALL.....Incomplete results data: Is there differential missingness (more than 20%) between arms for any eligible outcome? No
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Quality Rating
No quality rating data was found.