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Study Title and Description

Comparison of cryotherapy with curettage in the treatment of Bowen's disease: a prospective study.



Key Questions Addressed
1 Comparison of interventions
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Primary Publication Information
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TitleData
Title Comparison of cryotherapy with curettage in the treatment of Bowen's disease: a prospective study.
Author Ahmed I., Berth-Jones J., Charles-Holmes S., O'Callaghan CJ., Ilchyshyn A.
Country Department of Dermatology, Walsgrave Hospital NHS Trust, Coventry CV2 2DX, UK.
Year 2000
Numbers Pubmed ID: 11069453

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Comparative studies
Arms
Number Title Description Comments
1 Curettage
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2 Cryotherapy
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Design Details
Question... Follow Up Answer Follow-up Answer
Publication or abstract? Publication
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Study design Prospective nRCS
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Multicenter etc. Multicenter
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Country/Region UK
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Funding NR
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Inclusion criteria clinical diagnosis of Bowen's Disease
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Exclusion criteria Patients with recurrent lesions and those on immunosuppression were excluded
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N Enrolled/Randomized/Analyzed 73
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67
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Notes/Comments Patients were allocated to have treatment according to the established practice of the dermatologist in charge.
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Method of diagnosis ... Describe Biopsy/pathologic confirmation ... After the clinical diagnosis of BD was made, a 4-mm punch biopsy was taken
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Percent non-primary (recurrent) o
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Secondary size assessment
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Baseline Characteristics
Question Curettage Cryotherapy Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up
Continuous baselines 74
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46, 89
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336 mm2
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30, 1890 mm2
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Gender/Racial descent 55
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82
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Lesion location 38 29
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86 81
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2 4
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5 11
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trunk trunk
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head and neck 4 (9%) head and neck 3 (8%)
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Skin type (Fitzpatrick score) No data entered.
Number of lesions per patient No data entered.
Previous treatments No data entered.
Immunocompromized status No data entered.
Number of patients/lesions 73
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86
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67 for 2 week measures; 48 for recurrence measures
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80 for 2 week measures; 59 for recurrence
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Lesion extent number of people No data entered.
Lesion extent number of people No data entered.



Results & Comparisons


Results Data
Outcome: Lack of clinical clearance      Population: All Participants
Time Point Measure Curettage Cryotherapy


2 weeks

N Analyzed 44 lesions 36 lesions
Counts 0 2 lesions
Outcome: Recurrence or relapse      Population: All Participants
Time Point Measure Curettage Cryotherapy


22 months

N Analyzed 44 lesions 36 lesions
Counts 4 lesions 13 lesions
Odds Ratio (OR) P-Value
Outcome: Adverse events: pain      Population: All Participants Between-Arm Comparisons
Time Point Measure Curettage Cryotherapy Comparison Measure Cryotherapy vs. Curettage


1 days

N Analyzed 44 lesions 36 lesions 10.4
Counts <0.001


Quality Dimensions
Dimension Value Notes Comments
RCT:....Adequate generation of a randomized sequence reported
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RCT:....Adequate allocation concealment reported
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RCT:....Adequate blinding of PATIENTS reported
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RCT:....Adequate blinding of PROVIDERS reported
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ALL....Adequate blinding of OUTCOME ASSESSORS reported No
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ALL.....Incomplete results data: are more than 20% missing for any eligible outcome in any group?
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ALL.....Selective Reporting (judgement - put directly into notes field).
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RCT.....Is the treatment effect by Intention to treat?
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ALL....Group similarity at baseline. Unsure Baseline data not given by arm except lesion location, which was balanced
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ALL....Additional Bias: Bias due to problems not covered elsewhere. (judgement - put directly into notes field)
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ALL (with AE results)....Were reported adverse events (of interest) precisely defined Unsure dropouts not given by arm
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Overall, by outcome (judgement - put directly into notes field) high risk of bias for all outcomes
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ALL.....Incomplete results data: Is there differential missingness (more than 20%) between arms for any eligible outcome? Unsure okay for clinical clearance and pain; problematic for recurrence
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Quality Rating
No quality rating data was found.