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Project: Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis (2016)

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Title and Description

Title Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis (2016)
Description OBJECTIVES: The primary aim of this review was to assess the effectiveness of doxycycline plus ivermectin versus ivermectin alone for prevention and treatment of onchocerciasis. The secondary aim was to assess the effectiveness of doxycycline plus ivermectin versus ivermectin alone for prevention and treatment of onchocercal ocular lesions in communities co-endemic for onchocerciasis and Loa loa (loiasis) infection.
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Contributor(s) Abegunde AT, Ahuja RM, Okafor NJ. Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD011146. DOI: 10.1002/14651858.CD011146.pub2.
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Methodology SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (Issue 7, 2015), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to July 2015), EMBASE (January 1980 to July 2015), PubMed (1948 to July 2015), Latin American and Caribbean Health Sciences Literature Database (LILACS) (1982 to July 2015), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) (last searched 1 July 2014), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic search for trials. We last searched the electronic databases on 15 July 2015. SELECTION CRITERIA: We included randomized controlled trials (RCTs) that had compared doxycycline plus ivermectin versus ivermectin alone. Participants with or without one or more characteristic signs of ocular onchocerciasis resided in communities where onchocerciasis was endemic. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial eligibility and extracted data. We used standard methodological procedures as expected by Cochrane.
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DOI
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Funding Source Grant 1 U01 EY020522, National Eye Institute, National Institutes of Health, USA
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Notes Available on PubMed at https://www.ncbi.nlm.nih.gov/pubmed/26771164; PMID: 26771164; PMCID: PMC5029467 Data retrospectively entered into SRDR for public accessibility.
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Key Questions

1 What is the effect of doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis?
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Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis 2016 Long Long 1


Associated Studies (each link opens a new tab)

Title Author Year
Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study. Hoerauf A., Specht S., Büttner M., Pfarr K., Mand S., Fimmers R., Marfo-Debrekyei Y., Konadu P., Debrah AY., Bandi C., Brattig N., Albers A., Larbi J., Batsa L., Taylor MJ., Adjei O., Büttner DW. 2008
Effects of Ivermectin with and without doxycycline on clinical symptoms of onchocerciasis. Masud H., Qureshi TQ., Dukley M. 2009
Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial. Turner JD., Tendongfor N., Esum M., Johnston KL., Langley RS., Ford L., Faragher B., Specht S., Mand S., Hoerauf A., Enyong P., Wanji S., Taylor MJ. 2010




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The data contained in this project are distributed under the terms of the Creative Commons Attribution-NonCommerical license, which permits the use, dissemination, and reproduction in any medium, provided the original work is properly cited, and that the use is non-commercial and otherwise in compliance with the license. See: https://creativecommons.org/licenses/by-nc/3.0/