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Project: Medical interventions for acanthamoeba keratitis (2015)

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Project Summary

Title and Description

Title Medical interventions for acanthamoeba keratitis (2015)
Description OBJECTIVES: To evaluate the relative effectiveness and safety of medical therapy for the treatment of AK.
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Contributor(s) Alkharashi M, Lindsley K, Law HA, Sikder S. Medical interventions for acanthamoeba keratitis. Cochrane Database of Systematic Reviews 2015, Issue 2. Art. No.: CD010792. DOI: 10.1002/14651858.CD010792.pub2.
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Methodology SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2015, Issue 1), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to January 2015), EMBASE (January 1980 to January 2015), PubMed (1948 to January 2015), Latin American and Caribbean Health Sciences Literature Database (LILACS) (1982 to January 2015), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic search for trials. We last searched the electronic databases on 9 January 2015. SELECTION CRITERIA: We included randomized controlled trials (RCTs) of medical therapy for AK, regardless of the participants' age, sex, or etiology of disease. We included studies that compared either anti-amoeba therapy (drugs used alone or in combination with other medical therapies) with no anti-amoeba therapy or one anti-amoeba therapy with another anti-amoeba therapy. DATA COLLECTION AND ANALYSIS: Two authors independently screened search results and full-text reports, assessed risk of bias, and abstracted data. We used standard methodological procedures as set forth by the Cochrane Collaboration.
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DOI
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Funding Source Grant 1 U01 EY020522, National Eye Institute, National Institutes of Health, USA
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Notes Available on PubMed at https://www.ncbi.nlm.nih.gov/pubmed/25710134; PMID: 25710134; PMCID: PMC4730543 Data retrospectively entered into SRDR for public accessibility.
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Key Questions

1 What are the medical interventions for acanthamoeba keratitis?
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Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Medical interventions for acanthamoeba keratitis 2015 Long Long 1


Associated Studies (each link opens a new tab)

Title Author Year
Comparison of polyhexamethylene biguanide and chlorhexidine as monotherapy agents in the treatment of Acanthamoeba keratitis. Lim N., Goh D., Bunce C., Xing W., Fraenkel G., Poole TR., Ficker L. 2008




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The data contained in this project are distributed under the terms of the Creative Commons Attribution-NonCommerical license, which permits the use, dissemination, and reproduction in any medium, provided the original work is properly cited, and that the use is non-commercial and otherwise in compliance with the license. See: https://creativecommons.org/licenses/by-nc/3.0/