Advanced Search

Study Preview



Study Title and Description

Is YAG laser iridotomy useful in case of pigmentary glaucoma?



Key Questions Addressed
1 What is the effect of peripheral iridotomy for pigmentary glaucoma?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Is YAG laser iridotomy useful in case of pigmentary glaucoma?
Author Uva M, Avitabile T, Russo V, Ott J, D'Agata V, Reibaldi A
Country
Year 1996
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Peripheral iridotomy for pigmentary glaucoma 2016
Arms
Number Title Description Comments
1 Peripheral laser iridotomy iridotomy using a yttrium–aluminum–garnet (YAG) laser
  • Comments Comments (
    0
    ) |
2 No treatment
  • Comments Comments (
    0
    ) |

Design Details
Question... Follow Up Answer Follow-up Answer
Study design paired-eye, randomized controlled trial
  • Comments Comments (
    0
    ) |
Number randomly assigned 32 eyes of 16 participants; the fellow eye of each participant was the control
  • Comments Comments (
    0
    ) |
Exclusions after randomization none reported
  • Comments Comments (
    0
    ) |
Losses to follow-up none reported
  • Comments Comments (
    0
    ) |
Number analyzed 32 eyes of 16 participants
  • Comments Comments (
    0
    ) |
Unit of analysis eye (both eyes per participant)
  • Comments Comments (
    0
    ) |
Handling of missing data none
  • Comments Comments (
    0
    ) |
Sample size and power calculation none reported
  • Comments Comments (
    0
    ) |
Country not reported
  • Comments Comments (
    0
    ) |
Mean age not reported
  • Comments Comments (
    0
    ) |
Gender not reported
  • Comments Comments (
    0
    ) |
Inclusion criteria bilateral pigmentary glaucoma under medical therapy
  • Comments Comments (
    0
    ) |
Exclusion criteria not reported
  • Comments Comments (
    0
    ) |
Equivalence of baseline characteristics not reported
  • Comments Comments (
    0
    ) |
Laser iridotomy using a yttrium–aluminum–garnet (YAG) laser
  • Comments Comments (
    0
    ) |
Control no treatment
  • Comments Comments (
    0
    ) |
Length of follow-up Planned: not reported Actual: mean 28 months (range 12 to 37 months)
  • Comments Comments (
    0
    ) |
Outcomes (primary and secondary outcomes not differentiated); change in IOP, progression of visual field damage, change in iris configuration measured by UBM, change in signs of pigmentary glaucoma (Krukenberg spindle, iris transillumination, trabecular meshwork pigmentation)
  • Comments Comments (
    0
    ) |
Intervals at which outcomes assessed not reported
  • Comments Comments (
    0
    ) |
Information on cost of interventions or quality of life none reported
  • Comments Comments (
    0
    ) |
Study period not reported
  • Comments Comments (
    0
    ) |
Trial registration none reported
  • Comments Comments (
    0
    ) |
Source of funding not reported
  • Comments Comments (
    0
    ) |
Disclosures of interest not reported
  • Comments Comments (
    0
    ) |
Subgroup analyses none reported
  • Comments Comments (
    0
    ) |
Random sequence generation (selection bias):Authors' judgement Low risk
  • Comments Comments (
    0
    ) |
Random sequence generation (selection bias):Support for judgement Investigators used a randomization table
  • Comments Comments (
    0
    ) |
Allocation concealment (selection bias):Authors' judgement Unclear risk
  • Comments Comments (
    0
    ) |
Allocation concealment (selection bias):Support for judgement Method of allocation concealment not reported
  • Comments Comments (
    0
    ) |
Masking of outcome assessors (detection bias)Visual field:Authors' judgement Unclear risk
  • Comments Comments (
    0
    ) |
Masking of outcome assessors (detection bias)Visual field:Support for judgement Masking of visual field examiners not reported
  • Comments Comments (
    0
    ) |
Masking of outcome assessors (detection bias)Intraocular pressure:Authors' judgement Unclear risk
  • Comments Comments (
    0
    ) |
Masking of outcome assessors (detection bias)Intraocular pressure:Support for judgement Masking of IOP assessors not reported
  • Comments Comments (
    0
    ) |
Incomplete outcome data (attrition bias):Authors' judgement Low risk
  • Comments Comments (
    0
    ) |
Incomplete outcome data (attrition bias):Support for judgement Investigators reported no participants lost to follow-up
  • Comments Comments (
    0
    ) |
Selective reporting (reporting bias):Authors' judgement Unclear risk
  • Comments Comments (
    0
    ) |
Selective reporting (reporting bias):Support for judgement No protocol or clinical trial registration record was available for assessment of selective outcome reporting. All outcomes mentioned in the Methods section of the conference abstract were reported in the Results section
  • Comments Comments (
    0
    ) |
Other bias:Authors' judgement Low risk
  • Comments Comments (
    0
    ) |
Other bias:Support for judgement None identified
  • Comments Comments (
    0
    ) |




Results & Comparisons


Results Data
Outcome: Proportion of participants with pigmentary glaucoma and progression of visual field loss      Population: All Participants
Time Point Measure Peripheral laser iridotomy No treatment


28 months

N Analyzed 16 16
Counts 2 2
Outcome: Iris configuration      Population: All Participants
Time Point Measure Peripheral laser iridotomy No treatment


28 months

N Analyzed 16 16
Counts 14 Not reported
Outcome: Pigment accumulation in the trabecular meshwork and on the iris      Population: All Participants
Time Point Measure Peripheral laser iridotomy No treatment


28 months

N Analyzed
Counts
Outcome: Need for additional topical medication      Population: All Participants
Time Point Measure Peripheral laser iridotomy No treatment


28 months

N Analyzed
Counts
Outcome: Intraocular pressure      Population: All Participants
Time Point Measure Peripheral laser iridotomy No treatment


28 months

N Analyzed 16; reported only that IOP was unchanged from baseline in each group 16; reported only that IOP was unchanged from baseline in each group
Outcome: Visual acuity      Population: All Participants
Time Point Measure Peripheral laser iridotomy No treatment


28 months

N Analyzed
Outcome: Change in aqueous melanin granules      Population: All Participants
Time Point Measure Peripheral laser iridotomy No treatment


28 months

N Analyzed
Outcome: Quality of life      Population: All Participants
Time Point Measure Peripheral laser iridotomy No treatment


28 months

N Analyzed

Adverse Events
Arm or Total Title Description Proportion of adverse events Comments
Peripheral laser iridotomy Any adverse event Not reported
  • Comments Comments (
    0
    ) |
No treatment
Total