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Project: Topical corticosteroids as adjunctive therapy for bacterial keratitis (2014)

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Project Summary

Title and Description

Title Topical corticosteroids as adjunctive therapy for bacterial keratitis (2014)
Description OBJECTIVES: The objective of the review was to assess the effectiveness and safety of corticosteroids as adjunctive therapy for bacterial keratitis. Secondary objectives included evaluation of health economic outcomes and quality of life outcomes.
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Contributor(s) Herretes S, Wang X, Reyes JMG. Topical corticosteroids as adjunctive therapy for bacterial keratitis. Cochrane Database of Systematic Reviews 2014, Issue 10. Art. No.: CD005430. DOI: 10.1002/14651858.CD005430.pub3.
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Methodology SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2014, Issue 6), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to July 2014), EMBASE (January 1980 to July 2014), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to July 2014), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 14 July 2014. We also searched the Science Citation Index to identify additional studies that had cited the only trial included in the original version of this review, reference lists of included trials, earlier reviews, and the American Academy of Ophthalmology guidelines. We also contacted experts to identify any unpublished and ongoing randomized trials. SELECTION CRITERIA: We included randomized controlled trials (RCTs) that had evaluated adjunctive therapy with topical corticosteroids in people with bacterial keratitis who were being treated with antibiotics. DATA COLLECTION AND ANALYSIS: We used the standard methodological procedures expected by The Cochrane Collaboration.
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DOI
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Funding Source Grant 1 U01 EY020522, National Eye Institute, National Institutes of Health, USA
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Notes Available on PubMed at https://www.ncbi.nlm.nih.gov/pubmed/25321340; PMID: 25321340; PMCID: PMC4269217 Data retrospectively entered into SRDR for public accessibility.
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Key Questions

1 What are the effects of topical corticosteroids as adjunctive therapy for bacterial keratitis?
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Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Topical corticosteroids as adjunctive therapy for bacterial keratitis 2014 Long Long 1


Associated Studies (each link opens a new tab)

Title Author Year
Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: double-blinded randomized clinical trial. Blair J., Hodge W., Al-Ghamdi S., Balabanian R., Lowcock B., Pan YI., Sherif H., AlMahmoud T., Fergusson D., Slomovic A. 2011
Topical steroids in the treatment of central and paracentral corneal ulcers. Carmichael TR., Gelfand Y., Welsh NH. 1990
Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT). Srinivasan M., Mascarenhas J., Rajaraman R., Ravindran M., Lalitha P., Glidden DV., Ray KJ., Hong KC., Oldenburg CE., Lee SM., Zegans ME., McLeod SD., Lietman TM., Acharya NR. 2012
Corticosteroids for bacterial corneal ulcers. Srinivasan M., Lalitha P., Mahalakshmi R., Prajna NV., Mascarenhas J., Chidambaram JD., Lee S., Hong KC., Zegans M., Glidden DV., McLeod S., Whitcher JP., Lietman TM., Acharya NR. 2009




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The data contained in this project are distributed under the terms of the Creative Commons Attribution-NonCommerical license, which permits the use, dissemination, and reproduction in any medium, provided the original work is properly cited, and that the use is non-commercial and otherwise in compliance with the license. See: https://creativecommons.org/licenses/by-nc/3.0/