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Completed Systematic Reviews




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Screening for Hypertension in Children and Adolescents: Systematic Review for the U.S. Preventive Services Task Force


Public Project Complete

Statistics: 43 Studies, 8 Key Questions, 1 Extraction Form,
Date Published: Dec 01, 2021 02:58PM
Description: A review of the evidence about screening for high blood pressure in children and adolescents to delay the onset of or reduce adverse health outcomes related to high blood pressure.
Contributor(s): The authors gratefully acknowledge the following individuals for their contributions to this project: Iris Mabry-Hernandez, MD, MPH AHRQ Medical Officer; Tracy Wolf, MD, MPH AHRQ Associate Scientific Director; Quyen Ngo-Metzger, MD, MPH, Professor Kaiser Permanente School of Medicine; current members of the U.S. Preventive Services Task Force; expert peer reviewers Alex Kemper, MD, MPH; Callie Brown, MD, MPH; and Joseph T. Flynn, MD, MS; three Federal partner reviewers; and RTI International–University of North Carolina EPC staff: Carol Woodell, BSPH; B. Lynn Whitener, DrPH; Sharon Barrell, MA; Rachel Clark, MPH; and Loraine Monroe.
DOI: DOI pending.
Funding Source: AHRQ
Methodology Description: We conducted a systematic review to evaluate the evidence about screening for high blood pressure in children and adolescents to delay the onset of or reduce adverse health outcomes related to high blood pressure. We searched 4 databases through September 3, 2019. Two investigators screened each abstract and full-text article for inclusion; abstracted data; and performed quality ratings, applicability ratings, and evidence grading. We qualitatively synthesized findings for each KQ by summarizing the characteristics and results of included studies in tabular or narrative format.

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SRDR Project Indexing


Public Project Complete

Statistics: 195 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Dec 01, 2021 02:54PM
Description: This is a Methods Research project that catalogs the various projects with publicly available data on the SRDR Webpage.
Contributor(s): Ian Saldanha, Bryant Smith
Funding Source: Agency for Healthcare Research and Quality
Methodology Description: None Provided

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Treatment of Depression in Children and Adolescents: A Systematic Review


Public Project Complete

Statistics: 92 Studies, 10 Key Questions, 1 Extraction Form,
Date Published: Nov 08, 2021 05:48PM
Description: The purpose of the review is to examine the efficacy and comparative effectiveness of both benefits and harms of commonly used types of nonpharmacological and pharmacological treatments of child and adolescent depressive disorders.
Contributor(s): The authors gratefully acknowledge the following individuals for their contributions to this project and deeply appreciate their considerable support, commitment, and contributions: Aysegul Gozu, M.D., M.P.H. and Kim Wittenberg, M.A., our AHRQ Task Order Officers; RTI International–University of North Carolina at Chapel Hill EPC staff: Rania Ali, M.P.H.; Sharon Barrell, M.A.; Josh Green, B.A.; Loraine Monroe; Christiane Voisin, M.S.L.S.; Rachel Weber, Ph.D.; Carol Woodell, B.S.P.H. We also thank representatives from the American Academy of Child and Adolescent Psychiatry (Heather Walter, Ronald Szabat, and Karen Ferguson). Finally, we thank Tiffany R. Farchione, M.D., Deputy Director (Acting), Division of Psychiatry Products, Center for Drug Evaluation and Research, Office of New Drugs, U.S. Food and Drug Administration
Funding Source: AHRQ
Methodology Description: We conducted a systematic review to evaluate the efficacy, comparative effectiveness, and moderators of benefits and harms of available nonpharmacological and pharmacological treatments for children and adolescent a confirmed diagnosis of a depressive disorder (DD)—major depressive disorder (MDD), persistent depressive disorder (PDD, previously termed dysthymia) or DD not otherwise specified (DD NOS). We searched five databases and other sources for evidence available from inception to May 29, 2019, dually screened the results, and analyzed eligible studies.

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Management of High-Need, High-Cost Patients: A “Best Fit” Framework Synthesis, Realist Review, and Systematic Review


Public Project Complete

Statistics: 109 Studies, 3 Key Questions, 2 Extraction Forms,
Date Published: Nov 05, 2021 01:06PM
Description: None Provided
Contributor(s): Nancy Berkman, Eva Chang, Julie Seibert, Rania Ali, Deborah S. Porterfield, Linda Jiang, Roberta Wines, Caroline Rains, Meera Viswanathan
DOI: DOI pending.
Funding Source: AHRQ
Methodology Description: In keeping with realist review methods, we will refine the scope of the review as we uncover evidence and focus the depth and breadth of the review. We will address KQ 1 using a “best fit” framework synthesis methodology and KQ 2 using a realist review methodology; with these approaches, all study designs, if relevant, are admissible for inclusion. We will answer KQ 3 using a systematic review methodology, resulting in admissible study designs being more limited.

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Interventions for Breathlessness in Patients with Advanced Cancer


Public Project Complete

Statistics: 50 Studies, 4 Key Questions, 1 Extraction Form,
Date Published: Nov 05, 2021 12:39PM
Description: To assess benefits and harms of non-pharmacological and pharmacological interventions for breathlessness in adults with advanced cancer.
Contributor(s): Sydney M. Dy, M.D. Arjun Gupta, M.D. Julie M. Waldfogel, PharmD Ritu Sharma, B.Sc. Allen Zhang, B.S. Josephine L. Feliciano, M.D. Ramy Sedhom, M.D. Jeff Day, M.D., M.A. Rebecca A. Gersten, M.D. Patricia M. Davidson, Ph.D., MEd, R.N., F.A.A.N Eric B. Bass, M.D., M.P.H.
DOI: DOI pending.
Funding Source: None Provided
Methodology Description: We included randomized controlled trials (RCTs) and observational studies with a comparison group evaluating benefits and/or harms and cohort studies reporting harms. Two reviewers independently screened search results, serially abstracted data, assessed risk of bias and graded strength of evidence (SOE) for key outcomes: breathlessness, anxiety, health-related quality of life (HRQOL) and exercise capacity. We performed meta-analyses when possible and calculated standardized mean differences (SMDs).

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