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Completed Systematic Reviews




Strategies to De-escalate Aggressive Behavior (DAB) in Psychiatric Patients


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Statistics: 29 Studies, 3 Key Questions, 2 Extraction Forms,
Date Published: Mar 21, 2019 09:12AM
Description: This small systematic review addresses interventions to prevent or de-escalate aggressive behavior and to reduce use of seclusion and restraint for aggressive behaviors. We focus on studies in acute health care settings, as to our knowledge no such review has been done using data from such settings.
Contributor(s): None Provided
Funding Source: AHRQ
Methodology Description: Data Sources: We searched MEDLINE®, Embase®, the Cochrane Library, Academic Search Premier, PsycINFO, and CINAHL from January 1, 1991, through February 3, 2016. We manually searched reference lists of pertinent reviews, included trials, and background articles to identify relevant citations that our searches might have missed. Eligible studies included randomized controlled trials (RCTs), cluster randomized trials (CRTs), and observational and noncontrolled studies with sample sizes greater than 100. Eligible studies were limited to acute care settings and adult patients with psychiatric disorders or severe psychiatric symptomatology (excluding dementia); they had to report on aggression or seclusion and restraint outcomes. Review Methods: Two investigators independently selected, extracted data from, and rated risk of bias of studies. Risk of bias and strength of evidence (SOE) were assessed only for controlled studies. Twenty-nine primary studies (from 31 articles) met inclusion criteria. Of these, 11 were controlled trials that provided eligible data for SOE grades. Only 4 of these trials took place in the United States. We grouped studies as follows: (1) staff training interventions, (2) risk assessment interventions, (3) multimodal interventions, (4) environmental interventions (including group psychotherapeutic options), and (5) medication protocols versus other medication protocols or alternative strategies. We organized results by three Key Questions; these covered benefits, harms, and potential modifying characteristics of these strategies.

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Aflibercept for neovascular age-related macular degeneration (2016)


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Statistics: 2 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: To assess and compare the effectiveness and safety of intravitreal injections of aflibercept versus ranibizumab, bevacizumab, or sham for treatment of patients with neovascular AMD.
Contributor(s): Sarwar S, Clearfield E, Soliman MK, Sadiq MA, Baldwin AJ, Hanout M, Agarwal A, Sepah YJ, Do DV, Nguyen QD. Aflibercept for neovascular age-related macular degeneration. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD011346. DOI: 10.1002/14651858.CD011346.pub2.
Funding Source: Grant 1 U01 EY020522, National Eye Institute, National Institutes of Health, USA
Methodology Description: SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (Issue 11, 2015), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to November 2015), EMBASE (January 1980 to November 2015), PubMed (1948 to November 2015), Latin American and Caribbean Health Sciences Literature Database (LILACS) (1982 to November 2015), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) (last searched December 4, 2014), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic search for trials. We last searched the electronic databases on November 30, 2015. SELECTION CRITERIA: We included randomized controlled trials (RCTs) in which aflibercept monotherapy was compared with ranibizumab, bevacizumab, or sham for participants with neovascular AMD who were treatment-naive. DATA COLLECTION AND ANALYSIS: We used standard methodological procedures of The Cochrane Collaboration for screening, data abstraction, and study assessment. Two review authors independently screened records, abstracted data, and assessed risk of bias of included studies; we resolved discrepancies by discussion or with the help of a third review author when needed.

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Antiangiogenic therapy with interferon alfa for neovascular age-related macular degeneration (2010)


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Statistics: 1 Study, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: OBJECTIVES: The aim of this review was to investigate interferon alfa as a treatment modality for neovascular age-related macular degeneration.
Contributor(s): Reddy U, Kryzstolik M.
Funding Source: None Provided
Methodology Description: SEARCH STRATEGY: We searched and identified trials from the Cochrane Central Register of Controlled Trials (CENTRAL), which contains the Cochrane Eyes and Vision Group Trials Register, in The Cochrane Library (Issue 2, 2005), MEDLINE (1966 to 2005/06 week 1), EMBASE (1980 to 2005/week 23), LILACS (Latin American and Caribbean Health Science Literature Database) (June 2005) and the reference lists of included studies. SELECTION CRITERIA: This review included randomized controlled trials evaluating interferon alfa therapy in people with neovascular age-related macular degeneration who were followed for at least one year. DATA COLLECTION AND ANALYSIS: Both review authors independently extracted data and assessed trial quality. No data synthesis was conducted as only one trial met the inclusion criteria.

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Combined surgery versus cataract surgery alone for eyes with cataract and glaucoma (2015)


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Statistics: 9 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: OBJECTIVES To assess the relative effectiveness and safety of combined surgery versus cataract surgery (phacoemulsification) alone for co-existing cataract and glaucoma. The secondary objectives include cost analyses for different surgical techniques for co-existing cataract and glaucoma.
Contributor(s): Zhang ML, Hirunyachote P, Jampel H
Funding Source: None Provided
Methodology Description: SEARCH METHODS We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2014, Issue 10), Ovid MEDLINE,Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to October 2014), EMBASE (January 1980 to October 2014), PubMed (January 1948 to October 2014), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to October 2014), the meta Register of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/e n). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 3 October 2014.We checked the reference lists of the included trials to identify further relevant trials. We used the Science Citation Index to search for references to publications that cited the studies included in the review. We also contacted investigators and experts in the field to identify additional trials.

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Corticosteroid implants for chronic non-infectious uveitis (2016)


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Statistics: 2 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: OBJECTIVES: To determine the efficacy and safety of steroid implants in people with chronic non-infectious posterior uveitis, intermediate uveitis, and panuveitis.
Contributor(s): Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J. Corticosteroid implants for chronic non-infectious uveitis. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD010469. DOI: 10.1002/14651858.CD010469.pub2.
Funding Source: Grant 1 U01 EY020522, National Eye Institute, National Institutes of Health, USA
Methodology Description: SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (Issue 10, 2015), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to November 2015), EMBASE (January 1980 to November 2015), PubMed (1948 to November 2015), Latin American and Caribbean Health Sciences Literature Database (LILACS) (1982 to November 2015), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) (last searched 15 April 2013), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic search for studies. We last searched the electronic databases on 6 November 2015.We also searched reference lists of included study reports, citation databases, and abstracts and clinical study presentations from professional meetings. SELECTION CRITERIA: We included randomized controlled trials comparing either fluocinolone acetonide (FA) or dexamethasone intravitreal implants with standard-of-care therapy with at least six months of follow-up after treatment. We included studies that enrolled participants of all ages who had chronic non-infectious posterior uveitis, intermediate uveitis, or panuveitis with vision that was better than hand-motion. DATA COLLECTION AND ANALYSIS: Two review authors independently reviewed studies for inclusion. Two review authors independently extracted data and assessed the risk of bias for each study.

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