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Completed Systematic Reviews




Antiangiogenic therapy with interferon alfa for neovascular age-related macular degeneration (2010)


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Statistics: 1 Study, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: OBJECTIVES: The aim of this review was to investigate interferon alfa as a treatment modality for neovascular age-related macular degeneration.
Contributor(s): Reddy U, Kryzstolik M.
Funding Source: None Provided
Methodology Description: SEARCH STRATEGY: We searched and identified trials from the Cochrane Central Register of Controlled Trials (CENTRAL), which contains the Cochrane Eyes and Vision Group Trials Register, in The Cochrane Library (Issue 2, 2005), MEDLINE (1966 to 2005/06 week 1), EMBASE (1980 to 2005/week 23), LILACS (Latin American and Caribbean Health Science Literature Database) (June 2005) and the reference lists of included studies. SELECTION CRITERIA: This review included randomized controlled trials evaluating interferon alfa therapy in people with neovascular age-related macular degeneration who were followed for at least one year. DATA COLLECTION AND ANALYSIS: Both review authors independently extracted data and assessed trial quality. No data synthesis was conducted as only one trial met the inclusion criteria.

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Combined surgery versus cataract surgery alone for eyes with cataract and glaucoma (2015)


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Statistics: 9 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: OBJECTIVES To assess the relative effectiveness and safety of combined surgery versus cataract surgery (phacoemulsification) alone for co-existing cataract and glaucoma. The secondary objectives include cost analyses for different surgical techniques for co-existing cataract and glaucoma.
Contributor(s): Zhang ML, Hirunyachote P, Jampel H
Funding Source: None Provided
Methodology Description: SEARCH METHODS We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2014, Issue 10), Ovid MEDLINE,Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to October 2014), EMBASE (January 1980 to October 2014), PubMed (January 1948 to October 2014), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to October 2014), the meta Register of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/e n). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 3 October 2014.We checked the reference lists of the included trials to identify further relevant trials. We used the Science Citation Index to search for references to publications that cited the studies included in the review. We also contacted investigators and experts in the field to identify additional trials.

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Corticosteroid implants for chronic non-infectious uveitis (2016)


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Statistics: 2 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: OBJECTIVES: To determine the efficacy and safety of steroid implants in people with chronic non-infectious posterior uveitis, intermediate uveitis, and panuveitis.
Contributor(s): Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J. Corticosteroid implants for chronic non-infectious uveitis. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD010469. DOI: 10.1002/14651858.CD010469.pub2.
Funding Source: Grant 1 U01 EY020522, National Eye Institute, National Institutes of Health, USA
Methodology Description: SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (Issue 10, 2015), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to November 2015), EMBASE (January 1980 to November 2015), PubMed (1948 to November 2015), Latin American and Caribbean Health Sciences Literature Database (LILACS) (1982 to November 2015), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) (last searched 15 April 2013), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic search for studies. We last searched the electronic databases on 6 November 2015.We also searched reference lists of included study reports, citation databases, and abstracts and clinical study presentations from professional meetings. SELECTION CRITERIA: We included randomized controlled trials comparing either fluocinolone acetonide (FA) or dexamethasone intravitreal implants with standard-of-care therapy with at least six months of follow-up after treatment. We included studies that enrolled participants of all ages who had chronic non-infectious posterior uveitis, intermediate uveitis, or panuveitis with vision that was better than hand-motion. DATA COLLECTION AND ANALYSIS: Two review authors independently reviewed studies for inclusion. Two review authors independently extracted data and assessed the risk of bias for each study.

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Corticosteroids for treating optic neuritis (2015)


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Statistics: 6 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: OBJECTIVES: The objective of this review was to assess the effects of corticosteroids on visual recovery in eyes with acute optic neuritis.
Contributor(s): Gal RL, Vedula SS, Beck R.
Funding Source: None Provided
Methodology Description: SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2015, Issue 4), MEDLINE (January 1950 to April 2015), EMBASE (January 1980 to April 2015), Latin American and Caribbean Health Sciences Literature (LILACS) (January 1982 to April 2015), PubMed (January 1946 to April 2015), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). There were no date or language restrictions in the electronic searches for trials. The metaRegister of Controlled Trials (mRCT) was last searched on 6 March 2014. The electronic databases were last searched on 7 April 2015. We also searched reference lists of identified trial reports for additional trials. SELECTION CRITERIA: We included randomized controlled trials (RCTs) that evaluated systemic corticosteroids, in any form, dose or route of administration, in people with acute optic neuritis. DATA COLLECTION AND ANALYSIS: We used standard methodological procedures expected by Cochrane.

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Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder - Psychotherapy Interventions


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Statistics: 20 Studies, 10 Key Questions, 7 Extraction Forms,
Date Published: Mar 21, 2019 09:12AM
Description: Comparison of the benefits and harms of second-generation antidepressants (SGAs), psychological treatment options as first-step interventions for adult outpatients with acute -phase major depressive disorder (MDD), and as second-step interventions for patients with MDD who did not achieve remission after a first treatment attempt with SGAs.
Contributor(s): Gerald Gartlehner, M.D., M.P.H. Bradley N. Gaynes, M.D., M.P.H. Halle R. Amick, M.S.P.H. Gary Asher, M.D., M.P.H. Laura C. Morgan, M.A. Emmanuel Coker-Schwimmer, M.P.H. Catherine Forneris, Ph.D., ABPP Erin Boland, B.A. Linda J. Lux, M.P.A. Susan Gaylord, Ph.D. Carla Bann, Ph.D. Christiane Barbara Pierl, Ph.D., M.P.H. Kathleen N. Lohr, Ph.D., M.Phil., M.A.
Funding Source: Agency for Heatlhcare Quality and Research
Methodology Description: For the Systematic Review, we worked with a Technical Expert Panel representing the consumer perspective and professional organizations, researchers, and payers with expertise in psychopharmacology, psychotherapy, complementary and alternative medicine (CAM), and exercise therapies for depression, to finalize our methodological approach. Five literature databases were searched and dually screened following established inclusion/exclusion criteria. Individual trials were abstracted and dually rated for risk of bias. We qualitatively synthesized the data by each individual comparison eligible within each Key Question, and when data were sufficient we augmented findings with quantitative analyses. We graded the strength of evidence for outcomes deemed as important or critical for decisionmaking.

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