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Completed Systematic Reviews




CER Management Strategies for Renal Artery Stenosis: 2014 Update


Public Project Complete

Statistics: 80 Studies, 3 Key Questions, 1 Extraction Form,
Date Published: Jun 29, 2018 03:31PM
Description: An update of the 2006 and 2007 CERs comparing medical treatment, angioplasty+-stenting, and open vascular procedures for atherosclerotic renal artery stenosis. The update reviews only angioplasty with stenting (not an update of angioplasty without stenting).
Contributor(s): Ethan BALK, Gowri RAMAN, Gaelen ADAM, Ijeoma AZODO, Brown EPC, Brown University School of Public Health, Providence, RI
DOI: DOI pending.
Funding Source: AHRQ (EPC)
Methodology Description: See: https://effectivehealthcare.ahrq.gov/ehc/products/606/2037/renal-update-2015-150115.pdf

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Phenotypes and body mass in women with PCOS identified in Referral vs. Unselected populations: systematic review and meta-analysis


Public Project Complete

Statistics: 43 Studies, 2 Key Questions, 1 Extraction Form,
Date Published: Jun 29, 2018 03:31PM
Description: Objective: To compare the prevalence of PCOS phenotypes and obesity of PCOS women seen in the clinical (referred) setting vs. those identified in general population.
Contributor(s): Daria Lizneva, Richard Kirubakaran, Katerina Mykhalchenko, Larisa Suturina, Chernukha Galina, Michael P. Diamond, Ricardo Azziz.
Funding Source: Funds from the Career Development Award (MD Medical Group) were used to support D.L. throughout the manuscript preparation. No other funding recourses were identified.
Methodology Description: Objective: To compare the prevalence of polycystic ovary syndrome (PCOS) phenotypes and obesity among patients detected in referral versus unselected populations. Design: Systematic review and meta-analysis. Setting: Not applicable. Patient(s): Thirteen thousand seven hundred ninety-six reproductive-age patients with PCOS, as defined by the extended 2003 Rotterdam criteria. Intervention(s): Review of PUBMED, EMBASE, and Cochrane Library, 2003–2016. Only observational studies were included. Data were extracted using a web-based, piloted form and combined for meta-analysis. Main Outcome Measure(s): PCOS phenotypes were classified as follows: phenotype A, clinical and/or biochemical hyperandrogenism (HA) + oligo-/anovulation (OA) + polycystic ovarian morphology (PCOM); phenotype B, HA+OA; phenotype C, HA+PCOM; and phenotype D, OA+PCOM. Result(s): Forty-one eligible studies, reporting on 43 populations, were identified. Pooled estimates of detected PCOS phenotype prevalence were consequently documented in referral versus unselected populations, as [1] phenotype A, 50% (95% confidence interval [CI], 46%–54%) versus 19% (95% CI, 13%–27%); [2] phenotype B, 13% (95% CI, 11%–17%) versus 25% (95% CI, 15%–37%); [3] phenotype C, 14% (95% CI, 12%–16%) versus 34% (95% CI, 25–46%); and [4] phenotype D, 17% (95% CI, 13%–22%) versus 19% (95% CI, 14%– 25%). Differences between referral and unselected populations were statistically significant for phenotypes A, B, and C. Referral PCOS subjects had a greater mean body mass index (BMI) than local controls, a difference that was not apparent in unselected PCOS. Conclusion(s): The prevalence of more complete phenotypes in PCOS and mean BMI were higher in subjects identified in referral versus unselected populations, suggesting the presence of significant referral bias.

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Omega-3 fatty acids for adults with depression (Topic 4 in Data Abstraction Assistant [DAA] Trial)


Public Project Complete

Statistics: 0 Studies, 1 Key Question, 0 Extraction Forms,
Date Published: Jun 28, 2018 07:19PM
Description: This SRDR project was created to house the data abstraction forms (as PDFs) for the systematic review on omega-3 fatty acids for adults with depression. This systematic review was used as Topic 4 to identify studies for data abstraction during the Data Abstraction Assistant (DAA) Trial. The DAA Trial is registered with the National Information Center on Health Services Research and Health Care Technology (NICHSR) HSRP20152269. Registered November 9, 2015. https://wwwcf.nlm.nih.gov/hsr_project/view_hsrproj_record.cfm?NLMUNIQUE_ID=20152269&SEARCH_FOR=Tianjing%20Li
Contributor(s): None Provided
DOI: DOI pending.
Funding Source: None Provided
Methodology Description: None Provided

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Interventions to promote physical activity in cancer survivors (Topic 3 in Data Abstraction Assistant [DAA] Trial)


Public Project Complete

Statistics: 0 Studies, 1 Key Question, 0 Extraction Forms,
Date Published: Jun 28, 2018 07:19PM
Description: This SRDR project was created to house the data abstraction forms (as PDFs) for the systematic review on interventions to promote physical activity in cancer survivors. This systematic review was used as Topic 3 to identify studies for data abstraction during the Data Abstraction Assistant (DAA) Trial. The DAA Trial is registered with the National Information Center on Health Services Research and Health Care Technology (NICHSR) HSRP20152269. Registered November 9, 2015. https://wwwcf.nlm.nih.gov/hsr_project/view_hsrproj_record.cfm?NLMUNIQUE_ID=20152269&SEARCH_FOR=Tianjing%20Li
Contributor(s): None Provided
DOI: DOI pending.
Funding Source: None Provided
Methodology Description: None Provided

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Proprotein convertase subtilisin/kexin type 9 (PCSK-9) antibodies for adults with hypercholesterolemia (Topic 2 in Data Abstraction Assistant [DAA] Trial)


Public Project Complete

Statistics: 0 Studies, 1 Key Question, 0 Extraction Forms,
Date Published: Jun 28, 2018 07:16PM
Description: This SRDR project was created to house the data abstraction forms (as PDFs) for the systematic review on PCSK-9 antibodies for adults with hypercholesterolemia. This systematic review was used as Topic 2 to identify studies for data abstraction during the Data Abstraction Assistant (DAA) Trial. The DAA Trial is registered with the National Information Center on Health Services Research and Health Care Technology (NICHSR) HSRP20152269. Registered November 9, 2015. https://wwwcf.nlm.nih.gov/hsr_project/view_hsrproj_record.cfm?NLMUNIQUE_ID=20152269&SEARCH_FOR=Tianjing%20Li
Contributor(s): None Provided
DOI: DOI pending.
Funding Source: None Provided
Methodology Description: None Provided

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