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Completed Systematic Reviews




Management of Uterine Fibroids


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Statistics: 109 Studies, 4 Key Questions, 1 Extraction Form,
Date Published: Mar 08, 2017 04:15PM
Description: We assessed the evidence about management of uterine fibroids. Specifically, we sought to determine effectiveness of interventions, risks of harm, and whether individual or fibroid characteristics influence outcomes.
Contributor(s): Katherine E. Hartmann, MD, PhD Christopher Fonnesbeck, PhD Tanya Surawicz, MPH Shanthi Krishnaswami, MBBS, MPH Jeffrey C. Andrews, MD Jo Ellen Wilson, MD, MPH Digna Velez-Edwards, PhD, MS Shannon Kugley, MLIS
DOI: DOI pending.
Funding Source: None Provided
Methodology Description: We included studies published in English from January 1985 to September 2016. We identified randomized clinical trials to assess outcomes and harms of interventions. We used data from trials in a meta-analysis to estimate likelihood and timing of subsequent interventions for fibroids based on initial type of intervention. To describe risk of unrecognized leiomyosarcoma, we included studies that allowed calculation of prevalence of leiomyosarcoma discovered at the time of surgery for masses believed to be fibroids. We also identified publications that indicated operative approach to removal of leiomyosarcoma tissue and included survival data. We extracted data, assessed risk of bias, and rated the strength of the evidence for informing care.

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Lens extraction for chronic angle-closure glaucoma (2006)


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Statistics: 2 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Mar 06, 2017 03:13PM
Description: Background: Angle-closure glaucoma is characterized by obstruction to the outflow of aqueous humor and consequent rise in intraocular pressure. The obstruction may result from an anatomical predisposition of the eye or may be due to pathophysiologic processes in any part of the eye. The former is considered the primary form and the latter a secondary form of angle closure. Relative pupillary block obstructing free flow of aqueous from the posterior chamber of the eye to the anterior chamber is considered to be the most common mechanism of angle closure. Crowding of the angle is another mechanism, which often coexists with pupillary block. This can result from an anterior placement of the lens due to an increase in the thickness of the lens (as occurs with aging), anterior displacement by a posterior force (for example choroidal effusion), or laxity of the zonules. Objectives: The objective of this review was to assess the effectiveness of lens extraction for chronic primary angle-closure glaucoma compared with other interventions for the condition in people without past history of acute-angle closure attacks.
Contributor(s): Friedman D, Vedula SS. Lens extraction for chronic angle-closure glaucoma. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD005555. DOI: 10.1002/14651858.CD005555.pub2.
DOI: DOI pending.
Funding Source: National Eye Institute, National Institutes of Health, USA (Contract N-01-EY2-1003)
Methodology Description: Search methods: We searched CENTRAL (2005, Issue 3), MEDLINE (1950 to April 2006), EMBASE (1980 to April 2006), and LILACS (to August 2005). We searched the reference lists of included studies and used the Science Citation Index database. Selection criteria: In the absence of any randomized trials we included non-randomized studies comparing lens extraction with other treatment modalities for chronic primary angle-closure glaucoma including, but not limited to, laser iridotomy, medications, and laser iridoplasty. We excluded studies with a case-series design. Data collection and analysis: Two authors independently extracted data on methodological quality of the included studies, outcomes for the review, and study characteristics including participant characteristics, interventions, and sources of funding. Differences were resolved through discussion.

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Neuroprotection for treatment of glaucoma in adults (2013)


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Statistics: 1 Study, 1 Key Question, 1 Extraction Form,
Date Published: Mar 02, 2017 04:28PM
Description: Background: Glaucoma is a heterogeneous group of conditions involving progressive damage to the optic nerve, deterioration of retinal ganglion cells and ultimately visual field loss. It is a leading cause of blindness worldwide. Open angle glaucoma (OAG), the commonest form of glaucoma, is a chronic condition that may or may not present with increased intraocular pressure (IOP). Neuroprotection for glaucoma refers to any intervention intended to prevent optic nerve damage or cell death. Objectives: To systematically examine the evidence regarding the effectiveness of neuroprotective agents for slowing the progression of OAG in adults.
Contributor(s): Sena DF, Lindsley K. Neuroprotection for treatment of glaucoma in adults. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD006539. DOI: 10.1002/14651858.CD006539.pub3.
DOI: DOI pending.
Funding Source: National Eye Institute, National Institutes of Health, USA (Grant 1 U 01 EY020522)
Methodology Description: Search methods: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2012, Issue 9), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE, (January 1950 to October 2012), EMBASE (January 1980 to October 2012), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to October 2012), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. The electronic databases were last searched on 16 October 2012. Selection criteria: We included randomized controlled trials (RCTs) in which topical or oral treatments were used for neuroprotection in adults with OAG. Minimum follow up time was four years. Data collection and analysis: Two review authors independently reviewed titles and abstracts from the literature searches. Full-text copies of potentially relevant studies were obtained and re-evaluated for inclusion. Two review authors independently extracted data related study characteristics, risk of bias, and outcome data. One trial was identified for this review, thus we performed no meta-analysis. Two studies comparing memantine to placebo are currently awaiting classification until additional study details are provided. We documented reasons for excluding studies from the review.

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Acupuncture for glaucoma (2013)


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Statistics: 1 Study, 1 Key Question, 1 Extraction Form,
Date Published: Mar 02, 2017 04:26PM
Description: Background: Glaucoma is a multifactorial optic neuropathy characterized by an acquired loss of retinal ganglion cells at levels beyond normal age-related loss and corresponding atrophy of the optic nerve. Although many treatments are available to manage glaucoma, glaucoma is a chronic condition. Some patients may seek complementary or alternative medicine approaches such as acupuncture to supplement their regular treatment. The underlying plausibility of acupuncture is that disorders related to the flow of Chi (the traditional Chinese concept translated as vital force or energy) can be prevented or treated by stimulating relevant points on the body surface. Objectives: The objective of this review was to assess the effectiveness and safety of acupuncture in people with glaucoma.
Contributor(s): Law SK, Li T. Acupuncture for glaucoma. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD006030. DOI: 10.1002/14651858.CD006030.pub3.
DOI: DOI pending.
Funding Source: Contract N-01-EY-2-1003 and Grant 1 U01 EY020522-01, National Eye Institute, National Institutes of Health, USA
Methodology Description: SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2012, Issue 12), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to January 2013), EMBASE (January 1980 to January 2013), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to January 2013), Cumulative Index to Nursing and Allied Health Literature (CINAHL) (January 1937 to January 2013), ZETOC (January 1993 to January 2013), Allied and Complementary Medicine Database (AMED) (January 1985 to January 2013), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov), the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en) and the National Center for Complementary and Alternative Medicine web site (NCCAM) (http://nccam.nih.gov). We did not use any language or date restrictions in the search for trials. We last searched the electronic databases on 8 January 2013 with the exception of NCCAM which was last searched on 14 July 2010. We also handsearched Chinese medical journals at Peking Union Medical College Library in April 2007.We searched the Chinese Acupuncture Trials Register, the Traditional Chinese Medical Literature Analysis and Retrieval System (TCMLARS), and the Chinese Biological Database (CBM) for the original review; we did not search these databases for the 2013 review update. SELECTION CRITERIA: We included randomized controlled trials (RCTs) in which one arm of the study involved acupuncture treatment. DATA COLLECTION AND ANALYSIS: Two authors independently evaluated the search results and then full text articles against the eligibility criteria. We resolved discrepancies by discussion.

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Diet-Related Fibers and Human Health Outcomes, Version 3.0 (Retired)


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Statistics: 983 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Feb 17, 2017 03:08PM
Description: The objectives of this database are to: 1. Systematically compile and provide access to primary, English-language, peer-reviewed science linking dietary fiber intake in humans to one or more of 9 potential health benefits 2. Provide researchers with a tool to understand how different fibers are characterized in studies 3. Facilitate researchers in identifying gaps in the current research 4. Create a database to serve as a starting foundation of primary human literature for conducting evidence-based reviews and meta-analyses 5. Efficiently assist researchers in identifying fibers of interest. This database should serve as a foundation for future work. Specific inclusion and exclusion criteria, detailed in the user manual, were applied in determining database eligibility; thus, this database is not intended to serve as a sole source for identifying all possible fiber literature for the purposes of conducting a meta-analysis or systematic review. This database contains Population, Intervention, Comparator, and Outcome (PICO) data to help users formulate and narrow the focus of their research question. It is expected that secondary searches will be conducted to augment this database.
Contributor(s): Nicola McKeown (PI), Mei Chung (Co-I), Kara Livingston (Project & Data Manager), Caleigh Sawicki, Danielle Haslam, Deena Wang, Caitlin Blakeley, Yinan Jia, Nicole Baruch, Micaela Karlsen, Carrie Brown
DOI: DOI pending.
Funding Source: International Life Sciences Institute – North America branch (ILSI-NA)
Methodology Description: Please see user manual.

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