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Completed Systematic Reviews




Drug Therapy for Early Rheumatoid Arthritis in Adults: A Systematic Review Update


Public Project Complete

Statistics: 124 Studies, 4 Key Questions, 4 Extraction Forms,
Date Published: Mar 21, 2019 09:12AM
Description: The purpose of this systematic review is to update the 2012 Comparative Effectiveness Review that evaluated the benefits and harms of drug therapies for adults with rheumatoid arthritis (RA). This updated review has a targeted scope focusing solely on patients with early RA, defined as no more than one year of diagnosed disease. This report is intended to help health care decision makers -- patients, and clinicians, health system leaders, and policymakers, among others -- make well-informed decisions regarding early RA and thereby improve the quality of health care services.
Contributor(s): Katrina Donahue, M.D., M.P.H. Gerald Gartlehner, M.D., M.P.H. Elizabeth R. Schulman, M.D. Beth Jonas, M.D., F.A.C.R. Emmanuel Coker-Schwimmer, M.P.H. Sheila V. Patel, B.S.P.H. Rachel Palmieri Weber, Ph.D. Kathleen N. Lohr, Ph.D., M.Phil., M.A. Carla Bann, Ph.D. Meera Viswanathan, Ph.D.
Funding Source: Agency for Healthcare Research and Quality (AHRQ)
Methodology Description: To identify relevant published literature, we searched the following databases: MEDLINE® via PubMed, the Cochrane Library, Embase, and International Pharmaceutical Abstracts. Our literature searches included articles published from July 2010 to October 5, 2017. We manually searched the reference lists of included systematic reviews to supplement the main database searches. We ensured that our update added to the body of evidence found in the 2012 review, including new drugs approved by the U.S. Food and Drug Administration (FDA) or undergoing FDA review during our review period. We also searched the gray literature for unpublished studies relevant to this review, including: ClinicalTrials.gov, the World Health Organization International Clinical Trials Registry Platform, the New York Academy of Medicine’s Grey Literature Index, and Supplemental Evidence and Data information from targeted requests and from a Federal Register Notice (public invitation posted in the Federal Register to submit relevant study data to AHRQ on behalf of Evidence-based Practice Centers). To answer the Contextual Questions, we identified relevant literature opportunistically from our literature searches for KQs and used targeted literature searches to address remaining gaps in information.

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SRDR Project Indexing


Public Project Complete

Statistics: 132 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: This is a Methods Research project that catalogs the various projects with publicly available data on the SRDR Webpage.
Contributor(s): Ian Saldanha, Bryant Smith
Funding Source: Agency for Healthcare Research and Quality
Methodology Description: None Provided

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Lower Limb Prosthesis


Public Project Complete

Statistics: 20 Studies, 5 Key Questions, 2 Extraction Forms,
Date Published: Mar 21, 2019 09:12AM
Description: SR for AHRQ and CMS on psychometric properties of functional measures in lower limb amputees, heterogeneity of treatment effect of lower limb prostheses and components (LLP), and long term outcomes.
Contributor(s): Ethan M. Balk, M.D., M.P.H.; Abhilash Gazula, M.P.H.; Georgios Markozannes, M.Sc.; Hannah J. Kimmel, M.P.H.; Ian J. Saldanha, M.B.B.S., M.P.H., Ph.D.; Linda J. Resnik, Ph.D.; Thomas A. Trikalinos, M.D., Ph.D. Miranda Di, MD, PhD; Susan D'Andrea, PhD; Erin Twomey-Wilson, MS, MAS; Stacey Springs, PhD, Molly Magill, PhD
Funding Source: AHRQ EPC Program
Methodology Description: Standard systematic review, per AHRQ methodology. Literature searches conducted in PubMed, the Cochrane Central Trials Registry and Cochrane Database of Systematic Reviews, EMBASE, and CINAHL/PsycINFO databases through October 30, 2017.

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A Systematic Literature Review of Individuals’ Perspectives on Privacy and Genetic Information in the United States


Public Project Complete

Statistics: 9 Studies, 1 Key Question, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: As part of our Center focusing on understanding Genetic Privacy and Identity in Community Settings, we conducted a systematic literature review of what is already known about people’s concerns about genetic privacy in clinical care and research. We discovered that the research to date has focused primarily on concerns about downstream data users, issues of control, and whether data is revealed. Only recently have people been asked under what circumstances they might be willing to give up some privacy for another purpose. Remarkably little has been reported regarding the sociocultural factors that influence individuals’ opinions and decisions, even though these are where concerns can be addressed. Filling these gaps will be a major focus of our group’s research agenda.
Contributor(s): Ellen W. Clayton, Colin M. Halverson, Nila A. Sathe, Bradley A. Malin
Funding Source: National Human Genome Research Institute (NHGRI)
Methodology Description: We followed standard systematic review methodology including comprehensive searches of multiple databases, dual, independent screening of studies at the abstract and full text levels using a priori determined criteria; dual assessment of risk of bias; and data extraction by one investigator with checking by a second.

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Systematic Review on the Use of Cryotherapy Versus other Treatments for Basal Cell Carcinoma


Public Project Complete

Statistics: 38 Studies, 2 Key Questions, 1 Extraction Form,
Date Published: Mar 21, 2019 09:12AM
Description: Our objective is to determine the efficacy and adverse events profile of cryotherapy for the treatment of basal cell carcinoma compared to other therapeutic options or non intervention.
Contributor(s): Catherine N. Tchanque-Fossuo, MD, MS; Daniel B. Eisen, MD
Funding Source: No funding/sponsor was involved in the preparation of this manuscript.
Methodology Description: We systematically searched PubMed, OVID, the Cochrane Library, EMBASE, CINHAL, and CANCERLIT databases with the following search terms: “cryotherapy”, AND “basal cell carcinoma”, OR “cryosurgery” OR “cryoablation” uup to November 2016. Two independent reviewers screened the search results and extracted the databased on the inclusion criteria, while a third reviewer resolved any disagreement. The study endpoints included recurrence of basal cell carcinoma, cosmetic outcome, and healing time. The study quality was assessed using the Jadad scale.

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